Solitary glandular papilloma of the lung with molecular analysis: A case report and literature review.

Pathology, Research and Practice
Zoi EvangelouGeorgia Karpathiou

Abstract

Solitary papillomas of the lung are rare. One of their subtypes is glandular papilloma with only a very few cases described in the literature. We describe a case of pulmonary glandular papilloma with emphasis in its differential diagnosis and its molecular analysis. A 64-years old former smoker was incidentally found to have an endobronchial tumor of the right main bronchus. Microscopic and immunohistochemical findings revealed a glandular papilloma. EGFR, KRAS and BRAF V600E mutation analysis, as well as HPV detection analysis revealed no mutation or HPV infection. Detailed differential diagnosis and literature review are presented. Glandular papillomas of the lung are usually central, affecting older patients than squamous or mixed squamous cell and glandular papillomas. In previously reported cases, one glandular papilloma with KRAS mutation and another one with BRAF mutation have been reported. The present case harbored no mutation or HPV infection.

References

Aug 19, 2008·The American Journal of Surgical Pathology·Shinsuke AidaSeiichi Tamai
Aug 30, 2008·Journal of Thoracic Imaging·Motoo NakagawaSatoru Takahashi
Mar 20, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Stavros TryfonNikolaos Galanis
Mar 28, 2013·Case Reports in Pathology·Georgia KarpathiouAlexandra Giatromanolaki
Apr 27, 2018·Pathology International·Yuko KitawakiHironobu Sasano
Sep 16, 2019·Oral Oncology·Chrissa SiokaAthanasios Konstantinidis

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Citations

Feb 26, 2021·Histopathology·Katherine SyredAnnikka Weissferdt
May 8, 2021·Pathology, Research and Practice·Eiichi SasakiHiroaki Kuroda

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