Solitary peripheral ciliated glandular papillomas of the lung: a report of 3 cases

The American Journal of Surgical Pathology
Shinsuke AidaSeiichi Tamai

Abstract

We report 3 cases of solitary papillomas located in peripheral regions of the lung that are extremely rare in the literature. The patients were 75-year-old and 72-year-old men and a 53-year-old woman. One patient complained of recurrent hemoptysis. The other 2 had no symptoms, but abnormal nodular shadows were revealed by chest radiographs during a health check. The maximum diameters of the tumors were 1.0, 1.4, and 1.1 cm, respectively. The 3 tumors gave almost the same histologic findings. Papillomatous fronds lined by a stratified columnar epithelium were seen in the lumens of peripheral bronchi, bronchioles, or alveoli. The stratified columnar epithelium consisted of ciliated, mucous, and basal cells. The neoplastic epithelium extended to the alveolar region and showed a similar appearance to bronchioloalveolar or papillary type adenocarcinomas. For differential diagnosis, it is noteworthy that endobronchiolar papillomatous fronds constantly exist and spreading along alveolar walls is limited in adjacent alveoli in peripheral papillomas. The presence of ciliated cells and basal cells is considered an important finding to suggest benign character of the lesion.

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Citations

Mar 23, 2011·Pathology International·Kentaro InamuraTamiko Takemura
Oct 6, 2011·Archives of Pathology & Laboratory Medicine·Stephen M LaganaAlain C Borczuk
Jun 3, 2014·World Journal of Surgical Oncology·Shigeki SuzukiYuichiro Hayashi
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Aug 21, 2010·Interactive Cardiovascular and Thoracic Surgery·Shuichi SatoAkira Yokoyama
Oct 26, 2018·Archives of Pathology & Laboratory Medicine·Yen-Wen Lu, Yi-Chen Yeh
Mar 20, 2010·Diagnostic Cytopathology·Kyuichi KadotaYoshio Kushida
Mar 15, 2014·Korean Journal of Pathology·In Ho ChoiKyung-Jong Lee
Jan 30, 2020·Pathology International·Yuanyuan GuoJie Tong
Jul 28, 2016·The American Journal of Surgical Pathology·Liping LiuJennifer M Boland
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Oct 28, 2016·Pathology International·Tetsuo KonTetsuya Murata
Mar 17, 2021·Journal of Clinical Pathology·Yong YangHongcheng Liu
Feb 26, 2021·Histopathology·Katherine SyredAnnikka Weissferdt
Mar 7, 2020·Pathology, Research and Practice·Zoi EvangelouGeorgia Karpathiou
Mar 20, 2012·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Stavros TryfonNikolaos Galanis

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