PMID: 11316553Apr 24, 2001Paper

Solitary plasmacytoma treated with radiotherapy: impact of tumor size on outcome

International Journal of Radiation Oncology, Biology, Physics
R W TsangA K Stewart

Abstract

Solitary plasmacytoma (SP) is a rare presentation of plasma cell neoplasms. In contrast to multiple myeloma, long-term disease-free survival and cure is possible following local radiotherapy (RT), particularly for soft tissue presentations. In this study, we attempt to identify factors that predict for local failure, progression to multiple myeloma, and disease-free survival (DFS) in patients mainly managed with local RT. We identified 46 patients referred to the Princess Margaret Hospital between 1982 and 1993. The median age was 63 years (range 35-95), with a male:female ratio of 1.9:1. All patients had biopsy-proven SP (osseous: 32, soft tissue: 14). M-protein was abnormal in 19 patients (41%). All patients were treated with local RT (median dose 35 Gy), with 5 patients (11%) also receiving chemotherapy. Maximum tumor size pre-RT ranged from 0 to 18 cm (median 2.5). The 8-year overall survival, DFS, and myeloma-free rates were 65%, 44%, and 50%, respectively. The local control rate was 83%. Factors predictive of progression to myeloma (and poorer DFS) included bone presentation and older age. However, these two factors did not influence local control, which was affected by tumor size. All tumors < 5 cm in bulk (34 patients) ...Continue Reading

References

Jul 1, 1977·International Journal of Radiation Oncology, Biology, Physics·Z PetrovichR Barton
Mar 15, 1992·Cancer·J HollandB Fineberg
Feb 1, 1990·American Journal of Hematology·R AlexanianS Tucker
Apr 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·N A MayrA P Vigliotti
Jan 1, 1989·International Journal of Radiation Oncology, Biology, Physics·D A FrassicaR A Kyle
Jun 1, 1987·American Journal of Clinical Oncology·P GreenbergE Abemayor
Nov 1, 1980·International Journal of Radiation Oncology, Biology, Physics·C M MendenhallR R Million
Jan 1, 1981·Clinical Radiology·A R HarwoodD E Bergsagel
Sep 1, 1981·Radiology·S E BushM A Bagshaw
Sep 1, 1996·International Journal of Radiation Oncology, Biology, Physics·T W BolekN P Mendenhall
Aug 27, 1998·International Journal of Radiation Oncology, Biology, Physics·R H LiebrossR Alexanian
Jan 13, 1999·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·B Mitchell, P Brukner
Nov 24, 1999·The New England Journal of Medicine·S SinghalB Barlogie
Dec 2, 1999·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·R H LiebrossR Alexanian

❮ Previous
Next ❯

Citations

Feb 22, 2011·Annals of Hematology·Sonja KrauseDirk Neuhof
Apr 13, 2006·Clinical Rheumatology·Anna BlachEugene J Kucharz
Jun 12, 2002·Current Treatment Options in Oncology·Meletios A Dimopoulos, George Hamilos
Apr 6, 2004·Cancer radiothérapie : journal de la Société française de radiothérapie oncologique·L KochbatiM Maalej
Aug 5, 2006·Journal of Feline Medicine and Surgery·Paul J MellorMichael J Day
Sep 30, 2009·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Tal MaromYehudah Roth
Nov 11, 2003·American Journal of Otolaryngology·William M MendenhallNancy Price Mendenhall
Jun 14, 2002·International Journal of Radiation Oncology, Biology, Physics·Primoz StrojanAnton Munda
Jul 14, 2009·American Journal of Clinical Oncology·Roi DaganWilliam M Mendenhall
Apr 6, 2013·The Pan African Medical Journal·Maryame AhnachMeryem Quachouh
Jun 3, 2006·Blood·David DingliJerry A Katzmann
Aug 19, 2003·World Journal of Surgical Oncology·Rani Kanthan, Bahman Torkian
Sep 26, 2009·Journal of Hematology & Oncology·Muhammad Umar Jawad, Sean P Scully
Jan 15, 2011·JRSM Short Reports·George GarasTaran Tatla
Jul 7, 2011·Indian Journal of Medical and Paediatric Oncology : Official Journal of Indian Society of Medical & Paediatric Oncology·P Jovita M MartinLionel Rohit Mathew
Sep 10, 2013·Annals of Hematology·Shanqi GuoYizhuo Zhang
May 20, 2014·Annales de dermatologie et de vénéréologie·N MalissenL Meunier
May 30, 2014·Der Radiologe·M C Schmaus, D Neuhof
Aug 31, 2013·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Nicolas H von der HoehChristoph-Eckhard Heyde
Jan 16, 2014·Indian Journal of Hematology & Blood Transfusion : an Official Journal of Indian Society of Hematology and Blood Transfusion·Michael WebbVernon Louw
Nov 1, 2012·European Journal of Orthopaedic Surgery & Traumatology : Orthopédie Traumatologie·Massimiliano VisocchiGiulio Maira
Feb 27, 2008·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Jos Straetmans, Robert Stokroos
Dec 20, 2015·British Journal of Haematology·Paola FinsingerMaria T Petrucci
May 31, 2011·Critical Reviews in Oncology/hematology·Cyrus ChargariYoulia M Kirova
Sep 28, 2015·The Spine Journal : Official Journal of the North American Spine Society·Sebastian A AhmadiJan Frederick Cornelius
Nov 29, 2008·International Journal of Radiation Oncology, Biology, Physics·Paul J KimMichael P Mac Manus
Aug 19, 2008·International Journal of Radiation Oncology, Biology, Physics·Kimberly M CreachRobert A Kyle
Mar 11, 2004·British Journal of Haematology·Richard SoutarUNKNOWN British Society for Haematology
Jun 11, 2008·American Journal of Hematology·Sevil KilciksizUNKNOWN Turkish Oncology Group-Sarcoma Working Party
Sep 14, 2012·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Calvin C Y LimVisvaraja Subrayan
Oct 19, 2005·International Journal of Radiation Oncology, Biology, Physics·Mahmut OzsahinAbderrahim Zouhair
Feb 1, 2011·International Journal of Radiation Oncology, Biology, Physics·Ryohei SasakiSyogo Yamada
Jun 2, 2012·TheScientificWorldJournal·Sevil KilciksizAyfer Haydaroglu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

International Journal of Radiation Oncology, Biology, Physics
T W BolekNancy Price Mendenhall
International Journal of Radiation Oncology, Biology, Physics
Mahmut OzsahinAbderrahim Zouhair
Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
R H LiebrossRaymond Alexanian
International Journal of Radiation Oncology, Biology, Physics
R H LiebrossRaymond Alexanian
© 2021 Meta ULC. All rights reserved