Solubilisation of model adjuvants by Pluronic block copolymers

Journal of Colloid and Interface Science
Melissa A SharpTerence Cosgrove

Abstract

The effect of two model adjuvants (benzyl benzoate and benzyl alcohol) on the structure and dynamics of three Pluronic triblock copolymers (P85, P105 and F127) was studied using small-angle neutron scattering and pulsed-field gradient NMR. The two adjuvants studied have different aqueous solubilities. It was found that both adjuvants promoted the micellisation of the Pluronic block copolymers. In addition they lead to a swelling of the micelles, as shown by small-angle neutron scattering. From the pulsed-field gradient NMR results it was possible to determine the amount of adjuvant bound to the micelles.

References

Apr 18, 2000·Journal of Colloid and Interface Science·S VautheyH J Watzke
Apr 24, 2002·Physical Review. E, Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics·L LobryS H Chen
Feb 7, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Lise ArlethUlf Olsson
May 26, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·V CastellettoP Panine

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Citations

Apr 9, 2016·Advanced Drug Delivery Reviews·Hélène MalhaireFrédéric Lagarce
Aug 30, 2012·The Journal of Physical Chemistry. B·Shirin AlexanderStuart W Prescott
May 5, 2017·Physical Chemistry Chemical Physics : PCCP·Youngkyu HanChangwoo Do
Oct 24, 2018·Langmuir : the ACS Journal of Surfaces and Colloids·I GrilloS Prévost

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