PMID: 2884286Apr 1, 1987Paper

Solubilities and intrinsic dissolution rates of sulphamethoxazole and trimethoprim

The Journal of Pharmacy and Pharmacology
R DahlanV B Sunderland

Abstract

The influence of pH on the dissolution rates and solubilities of sulphamethoxazole and trimethoprim have been examined. Sulphamethoxazole was evaluated in buffers of ionic strength 0.5 mol dm-3 over the pH range 0.45-7.8 and at 25, 32 and 37 degrees C. The minimum solubility of sulphamethoxazole was 28.1 mg/100 mL at pH 3.22 and 25 degrees C. Solubilities increased significantly with both increased and decreased pH. Intrinsic dissolution rates demonstrated a linear relationship with the solubility data. Trimethoprim solubility was both buffer- and pH-dependent. In both water and hydrochloric acid solution at 32 degrees C the solubility of trimethoprim increased from 50 mg/100 mL in water at pH 8.54 to a maximum of 1550 mg/100 mL at pH 5.5. This maximum solubility was in excess of that predicted theoretically and may be due to supersaturation. Below pH 2 the solubility of protonated trimethoprim diminished from 1125 mg/100 mL with decreasing pH. This was due to the common ion effect. Intrinsic dissolution rates increased as pH was decreased with hydrochloric acid from 6.00 to 1.78, but decreased at pH 1.48 due to the common ion effect. Dissolution profiles of trimethoprim showed complex patterns dependent upon pH. The profile wa...Continue Reading

References

Feb 1, 1979·Journal of Pharmaceutical Sciences·J B Bogardus, R K Blackwood
May 1, 1985·The Journal of Pharmacy and Pharmacology·B P WallV B Sunderland
Dec 1, 1972·Journal of Pharmaceutical Sciences·S F Kramer, G L Flynn
Jan 1, 1973·Journal of Pharmaceutical Sciences·R H Manzo, M M De Bertorello
Nov 1, 1973·The Journal of Infectious Diseases·S A KaplanL Weissman
May 1, 1982·Journal of Pharmaceutical Sciences·J B Bogardus
Jan 1, 1981·Journal of Pharmaceutical Sciences·K G MooneyV J Stella
Jun 1, 1981·Journal of Pharmaceutical Sciences·S MiyazakiT Nadai
Jul 1, 1980·Journal of Pharmaceutical Sciences·J R Anderson, I H Pitman
Sep 1, 1980·Clinical Pharmacokinetics·R B Patel, P G Welling
Mar 1, 1962·Journal of Pharmaceutical Sciences·G LEVY, J A PROCKNAL

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Citations

Jan 17, 2004·International Journal of Pharmaceutics·Lawrence X YuAjaz S Hussain
Apr 24, 2014·Journal of Hazardous Materials·Hao ChenHui Li
May 27, 2006·Journal of Pharmaceutical Sciences·Aditya S Tatavarti, Stephen W Hoag
May 16, 2009·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Parvin Zakeri-MilaniHadi Valizadeh
Aug 7, 2004·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Marc LindenbergJennifer B Dressman
Jul 5, 2013·Journal of Zhejiang University. Science. B·Xuan HanXiao-E Yang
Nov 11, 2018·The Journal of Pharmacology and Experimental Therapeutics·Takanobu MatsuzakiAmin Rostami-Hodjegan

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