PMID: 6159909Sep 1, 1980Paper

Solubility and distribution of halothane in human blood

British Journal of Anaesthesia
Y C PangD E Brooks

Abstract

The interactions of halothane with five major constituents of human blood were studied by equilibrium dialysis. Haemoglobin, albumin, red cell membranes and triglycerides were found to contribute significantly to the solubility, and thus the transport, of halothane in whole blood. At physiological concentrations, gamma-globulin had no detectable effect on the solubility of halothane. Absorption isotherms of halothane binding to haemoglobin and albumin suggest a possible positive co-operative effect, but complete saturation of the binding sites was not observed even when the aqueous phase was saturated with halothane. The number of halothane molecules bound per albumin molecule was not significantly affected by the presence of oleic acid. For red cell ghosts and triglyceride-rich micelles (chylomicrons and very low density lipoprotein), the adsorption isotherms suggested that halothane is solubilized within the hydrophobic regions. The distribution of halothane between cells and plasma calculated from the above equilibrium dialysis results was in reasonable agreement with the distribution in whole blood determined by an independent method.

Citations

May 6, 1998·Comparative Biochemistry and Physiology. Part C, Pharmacology, Toxicology & Endocrinology·A K SinghY Jiang
Jun 1, 1990·Toxicology and Applied Pharmacology·C W LamD L Pierson
Nov 1, 2001·Journal of Cardiothoracic and Vascular Anesthesia·P HuJ Liu
Jun 2, 2017·Chemical Science·Liat AvramAmnon Bar-Shir
Apr 1, 1986·Journal of Applied Toxicology : JAT·C W LamD A Morken
Apr 19, 2012·Anesthesiology·Joao H N SoaresHong Liu
Dec 7, 2018·Journal of Chromatography. a·Raquel Dos SantosA Cecília A Roque
May 10, 1985·Journal of Chromatography·H Heusler

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