Solubility: it's not just for physical chemists

Drug Discovery Today
Shobha N BhattacharJames A Wesley


Solubility data are used to make crucial decisions from the earliest stages of drug discovery throughout the development process, but often the decision-maker is far removed, in terms of both organization and scientific background, from the scientist who generates the data. Here we provide a reference point for consumers of solubility who are presented with increasingly sophisticated strategies to measure sooner, faster or more accurately. We discuss the fundamental forces that govern solubility, the role of physical-chemical parameters such as pH and pK(a), and the principles involved in different solubility measurements. Our ultimate goal is to enable a decision-maker, when presented with solubility data, to have in hand the tools to evaluate not just the magnitude but also the context and appropriateness of those measurements to the drug in question.


Sep 1, 1978·Journal of Pharmaceutical Sciences·Z T Chowhan
Feb 1, 1979·Journal of Pharmaceutical Sciences·J B Bogardus, R K Blackwood
Jan 1, 1977·Journal of Pharmaceutical Sciences·S M BergeD C Monkhouse
Aug 1, 1987·The Journal of Pharmacy and Pharmacology·A T SerajuddinM A Augustine
Dec 1, 1972·Journal of Pharmaceutical Sciences·S F Kramer, G L Flynn
Aug 1, 1980·Journal of Pharmaceutical Sciences·S H Yalkowsky, S C Valvani
Jun 1, 1995·Journal of Pharmaceutical Sciences·Y SurakitbanharnS H Yalkowsky
May 7, 1999·Journal of Pharmaceutical Sciences·P LiS H Yalkowsky
Feb 13, 2001·Journal of Pharmaceutical Sciences·N Jain, S H Yalkowsky
Mar 20, 2002·Current Topics in Medicinal Chemistry·A Avdeef
Jul 13, 2002·Journal of Pharmaceutical Sciences·Zeren WangWilliam J Lambert
Dec 10, 2002·Combinatorial Chemistry & High Throughput Screening·Teng-Man ChenChegnyue Zhu
Oct 23, 2003·Drug Development and Industrial Pharmacy·Daniel WagnerPeter Langguth
Jul 22, 2004·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Christel A S BergströmPer Artursson
Nov 4, 2004·Journal of Pharmaceutical and Biomedical Analysis·Karen A DehringSalwa K Poole
Nov 24, 2004·Pharmaceutical Research·Xue-Qing Chen, Srini Venkatesh
Sep 2, 2005·Journal of Pharmaceutical Sciences·Shoufeng LiAbu T M Serajuddin
Dec 21, 2005·Journal of Pharmaceutical and Biomedical Analysis·Shobha N BhattacharChristopher Seadeek

❮ Previous
Next ❯


Nov 14, 2008·Pharmaceutical Research·Anne ZimmermannLars Hovgaard
Jun 25, 2009·Journal of Combinatorial Chemistry·Stuti SrivastavaAlexander Dömling
May 5, 2009·The AAPS Journal·Steven C Sutton
Aug 19, 2007·Expert Opinion on Drug Metabolism & Toxicology·Florian NigschSilvia Miret
Jul 8, 2009·International Journal of Molecular Sciences·Pablo R Duchowicz, Eduardo A Castro
Feb 4, 2014·Therapeutic Delivery·Hana Danan, Pierandrea Esposito
Jun 1, 2010·Expert Opinion on Drug Delivery·Pallavi Bassi, Gurpreet Kaur
Oct 25, 2014·Drug Development and Industrial Pharmacy·Shashank JainSenshang Lin
Oct 16, 2012·Expert Opinion on Drug Delivery·Luana Perioli, Cinzia Pagano
Apr 3, 2012·European Journal of Medicinal Chemistry·Carlos Hernández-CovarrubiasFrancisco Hernández-Luis
Sep 6, 2011·Journal of Pharmacological and Toxicological Methods·Yusheng QuHugo M Vargas
Jul 19, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Amit K Shah, Sunil A Agnihotri
Jun 15, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Loan HuynhChristine Allen
Feb 15, 2011·Journal of Pharmaceutical and Biomedical Analysis·A Szabados-NacsaZ Aigner
May 12, 2009·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Yun W AlelyunasCindy Shen
Aug 15, 2008·Bioorganic & Medicinal Chemistry·Pablo R DuchowiczEduardo A Castro
Dec 7, 2007·Drug Discovery Today·Lokesh KumarArvind K Bansal
Jun 30, 2007·Advanced Drug Delivery Reviews·J B DressmanC Reppas
Jul 15, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Raphael PausYuanhui Ji
Mar 21, 2012·Journal of Veterinary Pharmacology and Therapeutics·M N Martinez, R Fahmy
Sep 11, 2007·Drug Metabolism and Pharmacokinetics·Kiyohiko SuganoTakashi Mano
Apr 10, 2015·Journal of Pharmaceutical and Biomedical Analysis·Hideaki FurutaKatsuhide Terada
May 15, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Hannah K BatchelorUNKNOWN European Paediatric Formulation Initiative
Aug 16, 2011·Journal of Biomolecular Screening·John W EschelbachWolfgang Goetzinger
Apr 19, 2018·Pest Management Science·Yu ZhangMike R Loso
Aug 18, 2018·Biomedical Chromatography : BMC·Miao WangChunjie Zhao
Feb 7, 2013·Pharmacological Reviews·Hywel D WilliamsChristopher J H Porter
Sep 13, 2019·Drug Development and Industrial Pharmacy·Ardita VeseliAlbin Kristl
Jun 21, 2020·Antibiotics·Muhammad IdreesAyesha Rahman
Nov 24, 2017·Phytochemistry Reviews : Proceedings of the Phytochemical Society of Europe·Sanae MoudenKirsten A Leiss
Aug 23, 2008·Pharmaceutical Development and Technology·Lokesh KumarArvind K Bansal
May 13, 2020·Current Drug Delivery·Mori DhavalKiran Dudhat
Nov 18, 2020·European Journal of Medicinal Chemistry·Frauke AntoniGünther Bernhardt
Nov 4, 2017·Journal of Pharmaceutical Sciences·Katie L CavanaghNaír Rodríguez-Hornedo
Sep 29, 2019·Analytica Chimica Acta·Heidi BirchPhilipp Mayer
Apr 19, 2008·Journal of Medicinal Chemistry·Claudia LamannaLaura Maccari
Nov 3, 2009·Journal of Chemical Information and Modeling·M HewittJ C Dearden
Feb 21, 2019·Analytical Chemistry·Jernej ŠtukeljJouko Yliruusi

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences
S StegemannH Lindén
The Journal of Pharmacy and Pharmacology
Mariangeles Perez de la Cruz MorenoPatrick Augustijns
© 2021 Meta ULC. All rights reserved