Solubilization and anticancer-activity enhancement of Methotrexate by novel dendrimeric nanodevices synthesized in one-step reaction

Bioorganic Chemistry
Delia Soto-CastroPatricia Guadarrama

Abstract

The one-step synthesis of nanodevices based on PAMAM framework for targeted cancer therapy is described. Four water-soluble nanodevices (named fractions F1 to F4) were rightly separated by size discrimination, and characterized. From biological assays of cell growth inhibition percentage, the anticancer activity of Methotrexate (chemotherapeutic drug) as part of a nanodevice, generally increases over cancer cell lines and notably, in case of human lymphocytes, the cell growth inhibition percentage decreases drastically (more than 80%), thus, the nanodevices exhibited a favorable discrimination between healthy and diseased cells. From the characterization it can be conclude that the synthesized nanodevices provide a dual scenario of drug transportation: encapsulation and conjugation.

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Citations

Oct 26, 2016·Drug Discovery Today·Ashok Kumar SharmaUmesh Gupta
Nov 11, 2017·Therapeutic Delivery·Kaushalkumar Dave, Venkata Vamsi Krishna Venuganti
Feb 17, 2018·Archives of Pharmacal Research·Yejin KimDong Hee Na

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