Solubilization in vitro of tea tree oil and first results of antifungal effect in onychomycosis.

Enfermedades infecciosas y microbiología clínica
Felix Marcos-TejedorRaquel Mayordomo

Abstract

Onychomycosis is the main cause of nail alteration. Hepatotoxicity, interference and low adherence to pharmacological treatment are associated. Therefore, our objective was to assess the in vitro effectiveness of tea tree essential oil (less harmful) against main causative agents of these infections. Trichophyton rubrum and Trichophyton mentagrophytes were isolated and inoculated at a concentration of 3x105 CFU / mL in potato agar dextrose and tea tree essential oil at different concentrations to assess its effect by counting colony forming units and radial growth. Trichophyton rubrum growth inhibition was obtained at concentrations higher than 0.04% of the essential tea tree oil (p = 0.004). In the case of Trichophyton mentagrophytes, inhibition was obtained at 0.02% (p = 0.017), and even complete inhibition at a final concentration of the oil at 0.07%. Tea tree essential oil inhibits the in vitro growth of the fungus and may be a less harmful alternative to the onychomycosis treatment.

References

Mar 30, 2010·Revista iberoamericana de micología·Bibiana ZapataAna Cecilia Mesa-Arango
Apr 6, 2012·PLoS Pathogens·Rebecca Rashid Achterman, Theodore C White
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Jul 1, 2018·Journal of the American Academy of Dermatology·Shari R Lipner, Richard K Scher
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Nov 10, 2018·Skin Appendage Disorders·Aditya K Gupta, Rachel R Mays
Nov 5, 2019·Journal of Tissue Viability·Félix Marcos-TejedorAlfonso Martínez-Nova

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