Solubilization of neuroleptic/dopamine receptors of human brain striatum

European Journal of Pharmacology
A DavisP Seeman

Abstract

Dopaminergic neuroleptic receptors were solubilized by digitonin from post-mortem human brain putamen. The receptors were labelled by [3H]spiperone and separated from free [3H]spiperone by sephadex chromatography. Neuroleptics and neurotransmitters had similar inhibitory and stereoselective potencies on the solubilized and intact membrane receptors. The KD for [3H]spiperone was apparently high for the solubilized receptors. Unlike the rat striatum, therefore, the human putamen can be solubilized to release neuroleptic/dopamine receptors, permitting the future development of highly sensitive methods for detecting dopamine receptors.

References

Nov 1, 1978·European Journal of Pharmacology·S Tam, P Seeman
May 3, 1979·Nature·H Gorissen, P Laduron
Aug 27, 1979·Life Sciences·M GavishS H Snyder
Mar 9, 1978·Nature·J E LeysenP M Laduron
Aug 14, 1978·Life Sciences·H Gorissen, P M Laduron
Oct 2, 1978·Life Sciences·R S AronstamM E Eldefrawi
Feb 1, 1980·The American Journal of Psychiatry·T Lee, P Seeman
Jun 27, 1980·European Journal of Pharmacology·U T RüeggE J Simon
Jul 15, 1980·Biochemical Pharmacology·Y C Clement-CormierA McIsaac

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Citations

Dec 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·E Schömig, H Bönisch
Aug 15, 1984·Experientia·A Davis
Aug 27, 1981·European Journal of Pharmacology·B ChanP Seeman
Mar 26, 1982·European Journal of Pharmacology·B K MadrasP Seeman
Jun 16, 1982·European Journal of Pharmacology·B ChanB K Madras
Jan 21, 1983·European Journal of Pharmacology·A DavisS W Tang
Jan 1, 1985·Neurochemistry International·L LillyJ C Venter
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·J Ramwani, R K Mishra
Jan 1, 1981·Progress in Neuro-psychopharmacology·B K MadrasP Seeman
Mar 1, 1985·Journal of Neurochemistry·B K Madras, P Seeman
Dec 1, 1983·Journal of Neurochemistry·J M HallP G Strange
Jan 1, 1984·Journal of Neuroscience Research·K Moroi, L L Hsu
May 1, 1985·The Journal of Pharmacy and Pharmacology·G J KilpatrickC D Marsden
Jun 15, 1984·Biochemical Pharmacology·B F Kilpatrick, M G Caron
Apr 1, 1982·Biochemical Pharmacology·A DavisP Seeman
Nov 1, 1987·Molecular and Cellular Endocrinology·H B Niznik
Jun 30, 1982·Biochemical and Biophysical Research Communications·K ThermosD I Schuster

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