Solubilization of unconjugated bilirubin by bile salts

U Wosiewitz, S Schroebler


Freshly precipitated unconjugated bilirubin (UCB) is solubilized rapidly and to a large extent by the sodium salts of di- and trihydroxy bile acids. The solubilization effect depending on bile salt concentration, pH and ionic strength is based on micellar mechanisms.


Sep 1, 1988·Digestive Diseases and Sciences·T NakanoF Nakayma
Dec 1, 1996·Digestive Diseases and Sciences·H NoshiroK Chijiiwa
Jan 1, 1986·The Journal of Surgical Research·E L MullerH A Pitt
Nov 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·B W Trotman, R D Soloway
Sep 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J Donald Ostrow, L Celic
Jan 1, 1985·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·W W LaMorteL F Williams
Nov 2, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Marvin D Berman, Martin C Carey


Apr 14, 1978·Biochemical and Biophysical Research Communications·R Paul, P Balaram
Feb 1, 1962·Proceedings of the Society for Experimental Biology and Medicine·R C BURNSTINE, R SCHMID

Related Concepts

Bile Acid Measurement
Indirect reacting bilirubin
Bilirubin, (4E,15E)-Isomer
Sodium salts
Hydroxy Acids
Bile Salts
Hydrogen-Ion Concentration

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Synapse Loss as Therapeutic Target in MS

As we age, the number of synapses present in the human brain starts to decline, but in neurodegenerative diseases this occurs at an accelerated rate. In MS, it has been shown that there is a reduction in synaptic density, which presents a potential target for treatment. Here is the latest research on synapse loss as a therapeutic target in MS.

Artificial Intelligence in Cardiac Imaging

Artificial intelligence (ai) techniques are increasingly applied to cardiovascular (cv) medicine in cardiac imaging analysis. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

Social Learning

Social learning involves learning new behaviors through observation, imitation and modeling. Follow this feed to stay up to date on the latest research.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Single Cell Chromatin Profiling

Techniques like ATAC-seq and CUT&Tag have the potential to allow single cell profiling of chromatin accessibility, histones, and TFs. This will provide novel insight into cellular heterogeneity and cell states. Discover the latest research on single cell chromatin profiling here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells.