Soluble adhesion molecules, cytokines and cellular markers in serum in patients with acute infections

Scandinavian Journal of Infectious Diseases
L KulanderP Venge

Abstract

The aim of this study was to evaluate the diagnostic capacity of a number of blood components such as soluble adhesion molecules, interleukin-6 (IL-6), myeloperoxidase (MPO) and lysozyme in the distinction of acute bacterial and viral infections. Blood was taken from 115 acutely infected patients at admission before any treatment and in some cases on several consecutive days. 35 of the patients had a definite viral cause for their infection and 66 a bacterial cause. All variables were raised in patients with acute bacterial infections. Soluble vascular cell adhesion molecule-1 (sVCAM-1), sE-selectin, lysozyme and MPO were also raised in acute viral infections, but for sE-selectin and MPO less so than in bacterial infections. Evaluation of the diagnostic power showed that for MPO and IL-6 at cut-offs of 1300 microg/l and 100 ng/l, respectively, the positive predictive value was 97% and 100% and the negative predictive value 78% and 76%, respectively, in the classification of acute bacterial infections. In the distinction between viral or bacterial causes of acute infections in otherwise healthy subjects serum measurements of MPO and IL-6 are valuable tools and should be considered as diagnostic aids in the routine setting. The s...Continue Reading

References

Feb 20, 1975·The New England Journal of Medicine·E F Osserman
May 1, 1992·Journal of Clinical Microbiology·K A Near, M J Lefford
Jan 1, 1972·Seminars in Arthritis and Rheumatism·W Pruzanski, M A Ogryzlo
Apr 1, 1994·Journal of Endocrinological Investigation·R A DonaldA H Smith
Jul 1, 1993·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·T YamamotoE Ueta
Jan 1, 1993·Allergy·P Venge
Jan 1, 1993·Annual Review of Immunology·M P Bevilacqua
May 1, 1998·American Journal of Respiratory and Critical Care Medicine·V De RoseE Pozzi

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Citations

Jun 19, 2013·Diagnostic Microbiology and Infectious Disease·Julia WehUlrich Böcker
Dec 17, 2009·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Baris OzturkHakan Tuzun
Jan 28, 2005·Respiratory Medicine·Christer JansonUNKNOWN BHR-study group
Sep 2, 2003·International Journal of Cancer. Journal International Du Cancer·Eiichi TsujiMichio Kaminishi
Nov 5, 2005·Diabetes/metabolism Research and Reviews·Anna M ToivonenMikael Knip
Feb 27, 2015·Journal of Basic and Clinical Physiology and Pharmacology·Bamidele V OwoyeleSabitiu A Oyeleke
Sep 10, 2020·Animals : an Open Access Journal From MDPI·Rafał HrynkiewiczPaulina Niedźwiedzka-Rystwej
Jul 12, 2017·Journal of Dairy Science·Elke DepreesterGeert Opsomer
Jul 9, 2020·Scientific Reports·Mohanned Naif Alhussien, Ajay Kumar Dang
Oct 6, 2007·Scandinavian Journal of Infectious Diseases·Karlis PauksensPer Venge

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