Abstract
Glaucoma is one of the leading causes of visual impairment and blindness. It is characterized by excavation of optic nerve head and visual field loss. Even though the pathogenesis of glaucoma remains unclear, it is generally accepted that elevated intraocular pressure is the major risk factor. No matter what the specific initiators are, retinal ganglion cells are believed to die via apoptosis eventually. It is known that glaucoma correlates strongly with Alzheimer's disease and the two diseases share many similarities in pathogenic mechanisms. Recent studies have indicated that amyloid beta peptide, which is implicated in the progression of Alzheimer's disease, may be also responsible for retinal ganglion cells death in glaucoma. Amyloid beta exists in different forms, including monomers, oligomers and fibrils, and among these, as demonstrated by extensive evidences, soluble amyloid beta oligomers rather than insoluble amyloid beta fibrils induced apoptosis of neurons in Alzheimer's disease. Here we propose that soluble amyloid beta oligomers may play an important role in activation of apoptotic cascades in retinal ganglion cells in glaucoma.
References
Mar 8, 1997·Current Opinion in Ophthalmology·N Gupta, R N Weinreb
Nov 20, 2001·Ophthalmology·L M WeihH R Taylor
Jan 5, 2002·American Journal of Ophthalmology·Andreas U BayerKlaus-Peter Maag
Apr 5, 2002·Nature·Dominic M WalshDennis J Selkoe
Jan 4, 2003·The Journal of Clinical Investigation·Todd E Golde
Nov 5, 2003·Biochemistry·Brett A ChromyWilliam L Klein
May 3, 2005·The Journal of Clinical Investigation·Sam Gandy
Sep 10, 2005·Neuropathology and Applied Neurobiology·D T WalshL S Jen
Feb 21, 2006·The British Journal of Ophthalmology·H A Quigley, A T Broman
Citations
May 12, 2011·Age·Kin ChiuRaymond Chuen-Chung Chang
Jan 22, 2010·Journal of Genetics·Kunal Ray, Suddhasil Mookherjee
Oct 12, 2010·Neurochemical Research·Leandro T OliveiraSérgio T Ferreira
Sep 4, 2014·Experimental Brain Research·Hannah Harvey, Szonya Durant
May 9, 2012·Free Radical Biology & Medicine·Folami LamokeManuela Bartoli
Aug 13, 2015·PloS One·Lucia Y DuMonica L Acosta
Mar 1, 2018·The International Journal of Neuroscience·Mohd Aizuddin Mohd LazaldinNafeeza Mohd Ismail
May 31, 2018·Journal of Alzheimer's Disease : JAD·Erika N ClineWilliam L Klein
Feb 27, 2016·The Journal of Nervous and Mental Disease·Ah Reum JeongNa Rae Kim
Apr 9, 2010·Journal of Neurochemistry·Kazuhiro TsurumaHideaki Hara
Nov 21, 2012·Nature Reviews. Neurology·Anat LondonMichal Schwartz
Mar 8, 2012·Acta Ophthalmologica·Jean-Paul RenardCécile Delcourt
Nov 16, 2017·BioMed Research International·Luis Fernando Hernández-ZimbrónEdgar Zenteno
Apr 11, 2018·Frontiers in Cellular Neuroscience·Mojdeh AbbasiStuart L Graham
Dec 29, 2019·The European Journal of Neuroscience·Mohd Aizuddin Mohd LazaldinNafeeza Mohd Ismail
Aug 28, 2021·Biomolecules·Chunyan LiaoNancy Y Ip