Soluble Axl Is a Novel Diagnostic Biomarker of Hepatocellular Carcinoma in Chinese Patients with Chronic Hepatitis B Virus Infection.

Cancer Research and Treatment : Official Journal of Korean Cancer Association
Xiaoting SongChunyan Zhang

Abstract

The purpose of this study was to evaluate the diagnostic value of soluble Axl (sAxl) in hepatocellular carcinoma (HCC) in comparison with serum α-fetoprotein (AFP). Eighty HCC patients, 80 liver cirrhosis patients (LC), 80 patients with hepatitis B virus (HBV) infection, and 80 healthy controls (HC) were enrolled. sAxl levels were measured by an enzyme-linked immunosorbent assay, serum AFP levelswere measured by an electrochemiluminescence immunoassay. Receiver operating characteristic (ROC) curves were used to evaluate diagnostic performances. The results show that levels of sAxl were high expression in patients with HCC (p < 0.05), varied with disease state as follows: HCC > LC > HC > HBV. Logistic regression and ROC curve analysis identified the optimal cut-off for sAxl in differentiating all HCC and non-HCC patients was 1,202 pg/mL (area under the receiver operating characteristic [AUC], 0.888; 95% confidence interval [CI], 0.852 to 0.924) with sensitivity 95.0%, specificity 73.3%. Furthermore, differential diagnosis of early HCC with non-HCC patients for sAxl showed the optimal cut-off was 1,202 pg/mL (AUC, 0.881; 95% CI, 0.831 to 0.931; sensitivity, 94.1%; specificity, 73.3%). Among AFP-negative HCC patients with non-HCC ...Continue Reading

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Citations

Sep 15, 2020·Frontiers in Oncology·Ting Wang, Kun-He Zhang
Apr 16, 2021·The Cochrane Database of Systematic Reviews·Agostino ColliGiovanni Casazza
Aug 18, 2021·The International Journal of Biochemistry & Cell Biology·Lohit Khera, Sima Lev

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Methods Mentioned

BETA
surgical resection
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

sAxl
SPSS

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