Soluble CD40L levels are regulated by the -3459 A>G polymorphism and predict myocardial infarction and the efficacy of antithrombotic treatment in non-ST elevation acute coronary syndrome

Arteriosclerosis, Thrombosis, and Vascular Biology
Anders MälarstigAgneta Siegbahn

Abstract

Current evidence suggests the CD40-CD40L pathway as a key process in the development, progression, and outcome of acute coronary syndrome (ACS). The aim was to investigate the prognostic importance of soluble (s) CD40L levels, single nucleotide polymorphisms (SNP) in the CD40LG gene, and the relation between sCD40L and SNPs in patients with acute coronary syndromes (ACS). Samples were obtained on admission from 2359 patients with non-ST elevation ACS randomized to an early invasive versus a conservative and to placebo controlled long-term dalteparin treatment in the FRISC-II study. The -3459 A>G SNP was identified as a novel regulator of sCD40L levels (P = 0.001). In the placebo-treated group, sCD40L levels above median were associated with a 2.5-fold increased risk of myocardial infarction (MI) (P < or = 0.001) but not with raised mortality. In the dalteparin treated group, sCD40L showed no association with MI (P = 0.75). Consequently, dalteparin treatment was effective in reducing the risk of MI only in patients with sCD40L levels above median. A combined assessment of troponin-T and sCD40L complemented the prognostic information on risk of MI. We identified a SNP in the CD40LG gene as a novel regulator of sCD40L plasma conce...Continue Reading

References

Jan 1, 1976·Nephron·D W Cockcroft, M H Gault
Jan 7, 2000·The American Journal of Pathology·U SchönbeckP Libby
Jun 22, 2000·Proceedings of the National Academy of Sciences of the United States of America·R P Phipps
Sep 19, 2000·Virchows Archiv : an International Journal of Pathology·M J SzabolcsM J Yellin
Mar 5, 2002·Nature Medicine·Patrick AndréDenisa D Wagner
Dec 12, 2002·Journal of the American College of Cardiology·Bo LagerqvistUNKNOWN Fast Revascularization during InStability in Coronary artery disease-II Investigators
Mar 20, 2003·Journal of the American College of Cardiology·L Kristin NewbyE Magnus Ohman
Mar 21, 2003·The New England Journal of Medicine·Christopher HeeschenUNKNOWN CAPTURE Study Investigators
Aug 13, 2003·Circulation·Nerea VaroUwe Schönbeck
Dec 23, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yan JinchuanKong Xiantao
Jul 13, 2004·European Heart Journal·Juan F Viles-GonzalezJuan J Badimon
Feb 9, 2006·Blood Cells, Molecules & Diseases·Richard W Farndale

❮ Previous
Next ❯

Citations

Jun 26, 2010·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·B PinedaM Á García-Pérez
Jan 17, 2009·Analytical and Bioanalytical Chemistry·Ulrich Friess, Maik Stark
May 16, 2008·Journal of Clinical Immunology·Fu-Yuan HuangYann-Jinn Lee
Nov 29, 2007·Internal and Emergency Medicine·F SantilliG Davì
Feb 11, 2009·Evidence-based Complementary and Alternative Medicine : ECAM·Guangde YangRong Lin
Jun 27, 2012·Arthritis Research & Therapy·María TeruelJavier Martin
Jun 1, 2007·Biomarkers in Medicine·Xinkang WangGiora Z Feuerstein
Dec 6, 2014·International Journal of Molecular Sciences·Chaker AlouiOlivier Garraud
Sep 28, 2012·Thrombosis and Haemostasis·Patrizia FerroniGiovanni Davì
Mar 25, 2014·Neuroscience Letters·Bikui ZhangRen Guo
Jun 3, 2016·Journal of Human Lactation : Official Journal of International Lactation Consultant Association·Kelley L BaumgartelYvette P Conley
Sep 9, 2016·Biological Research for Nursing·Kelley L BaumgartelYvette P Conley
Nov 7, 2007·Circulation·Carrie L WelchAlan R Tall
Nov 4, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Wolfgang Koenig, Natalie Khuseyinova
Mar 31, 2010·Expert Review of Hematology·Donna S Woulfe
Jan 20, 2011·Annals of Medicine·Burak PamukcuEduard Shantsila
Jan 26, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sivaramakrishna P RachakondaThomas Luft
Dec 15, 2016·Frontiers in Immunology·Olivier GarraudF Cognasse
Sep 9, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Sae-H KimUNKNOWN Adverse Drug Reaction Research Group in Korea
Feb 22, 2012·International Journal of Cardiology·Sally J Aldous

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.