Abstract
Fifty-nine children with acute Kawasaki disease (KD), a childhood vasculitis, were compared with 35 children with fever due to infection and 48 healthy children. Levels of soluble E-selectin (sE-selectin), soluble intercellular adhesion molecule-1 (sICAM-1), and soluble vascular cell adhesion molecule-1 (sVCAM-1) in the healthy children were double those found in adults. All three soluble cell adhesion molecules and von Willebrand factor (vWF) were higher in the children with KD than in the healthy children, but only sE-selectin, a marker for activated endothelial cells, and sICAM-1 were higher than in the febrile children. The high levels of vWF in KD appear to reflect the prominent acute-phase reaction. This information can help us to understand further the complex interactions between cytokines, circulating inflammatory cells and the vascular endothelium, and may lead to new therapeutic avenues in KD and other inflammatory diseases and vasculitides.
References
Aug 17, 1978·European Journal of Pediatrics·S Hirose, Y Hamashima
Jun 1, 1992·Arthritis and Rheumatism·S FurukawaK Yabuta
Dec 1, 1991·Acta Paediatrica Japonica; Overseas Edition·D Y Leung
Aug 2, 1990·Nature·T A Springer
Jun 1, 1990·Clinical Pediatrics·J E IrazuztaA R Rees
Aug 7, 1986·The New England Journal of Medicine·J W NewburgerS P Sanders
Feb 15, 1989·Thrombosis Research·B E PottingerJ D Pearson
Dec 2, 1989·Lancet·D Y LeungJ S Pober
Jun 1, 1987·Annals of the Rheumatic Diseases·A D WoolfP A Dieppe
Jan 1, 1987·Rheumatology International·J J BelchR D Sturrock
Oct 1, 1993·Immunology Today·A J Gearing, W Newman
Aug 1, 1994·Arthritis and Rheumatism·C A StegemanC G Kallenberg
Jan 1, 1994·Scandinavian Journal of Rheumatology·D S Kim, K Y Lee
Apr 1, 1993·Arthritis and Rheumatism·J C MasonD O Haskard
Jun 1, 1993·Clinical and Experimental Immunology·S M WellicomeD O Haskard
Jan 1, 1994·Archives of Disease in Childhood·E AteşO Söylemezoğlu
Jul 1, 1994·Arthritis and Rheumatism·A F KavanaughP E Lipsky
Citations
Dec 1, 1996·Archives of Disease in Childhood·O SöylemezogluE Hasanoglu
Nov 1, 1996·Pediatric Hematology and Oncology·P FischerG Gaedicke
Jan 3, 2001·Pediatric Research·A Toivonen The Childhood Diabetes In Finl
Feb 7, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·J AraA Darnell
Oct 23, 2002·Clinical and Experimental Immunology·E GrunebaumY Shoenfeld
Mar 17, 2004·Arthritis and Rheumatism·P A BroganM J Dillon
May 1, 2010·Pediatric Cardiology·Cedric ManlhiotBrian W McCrindle
Nov 25, 2019·European Journal of Pediatrics·André JakobBarbara Zieger
May 13, 2005·Genes and Immunity·J C BurnsR M Cantor
Feb 28, 2003·Clinical and Experimental Immunology·K NakataniI Sekine
May 16, 2008·Journal of Clinical Immunology·Fu-Yuan HuangYann-Jinn Lee
Jun 29, 2012·Rheumatology·Tania CellucciSusanne M Benseler
Mar 15, 2020·Scientific Reports·Ying WangFangqi Gong
Dec 22, 1999·Clinical and Experimental Immunology·J FontP Engel
Sep 16, 2004·European Journal of Human Genetics : EJHG·Yoshihiro OnouchiAkira Hata
Nov 18, 2018·Arthritis & Rheumatology·Giulia ArmaroliChristoph Kessel
Mar 18, 2005·Pediatrics International : Official Journal of the Japan Pediatric Society·Ming-Tsan LinShwu-Jin Chiou
Aug 1, 1996·Pediatric Research·J ParonenH K Akerblom
Aug 19, 2010·Toxicologic Pathology·Jun ZhangThomas Colatsky
Jan 25, 2003·Coronary Artery Disease·Soichiro Kitamura
Aug 4, 2005·Indian Journal of Pediatrics·Monesha Gupta-Malhotra, P Syamasundar Rao
Jun 9, 2016·PloS One·John C WhitinHarvey J Cohen
Jan 28, 2005·European Heart Journal·Kausik K RayEugene Braunwald
Dec 5, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·S HopkinM Chimen
May 1, 1997·Clinical and Diagnostic Laboratory Immunology·P P Sfikakis, G C Tsokos
May 1, 1997·Baillière's Clinical Rheumatology·C G Kallenberg