Soluble chemokine CCR5 receptor is present in human plasma

Immunology Letters
Alexander TsimanisZvi Bentwich


In view of the natural resistance to infection by HIV and occasional delayed clinical manifestation of the disease, as also the fact that the virus is able to enter only cells that express CD4 and a co-receptor, we initiated a search for a soluble co-receptor that might compete with its membrane counterpart. Using a sandwich ELISA system, a soluble human CCR5 receptor (sCCR5) was indeed detected in the circulation. Immunoprecipitation of sCCR5-positive plasma samples from Israelis of Ethiopian and non-Ethiopian origin with mAb 2D7, a conformation-dependent anti-CCR5 antibody, revealed the presence of an approximately 22 kDa protein. A panel of antibodies directed against the membrane receptor was used to characterize the structure of the soluble CCR5: mAb CTC8, recognizing the N-terminal sequence of the protein, 10YDIN13; "multidomain" mAbs FAB181B and FAB183B that are dependent upon the presence of Q93 and D95 in ECL1 and K171 and E172 in ECL2A, and mAb FAB182B, recognizing the stretch 184YSQYQF189, which spans the C-terminal part of the second extracellular loop. The presence of short soluble CCR5 in human plasma has not been previously described. Among HIV-negative non-Ethiopian Israelis, 20.4% were sCCR5-positive, as agains...Continue Reading


Aug 1, 1997·Current Opinion in Immunology·J P MooreT Dragic
Dec 18, 1997·American Journal of Human Genetics·M CarringtonM Dean
Aug 26, 1998·Journal of Clinical Immunology·A Garzino-DemoR C Gallo
Apr 14, 1999·Proceedings of the National Academy of Sciences of the United States of America·H LiuT Shioda
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·B LeeR W Doms
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·T L HoffmanR W Doms
Jul 8, 1999·Proceedings of the National Academy of Sciences of the United States of America·K LingG Pei
Oct 16, 1999·Proceedings of the National Academy of Sciences of the United States of America·E GonzalezS K Ahuja
Jun 21, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·A KalinkovichZ Bentwich

❮ Previous
Next ❯


Aug 7, 2007·AIDS Research and Human Retroviruses·A BritoJ Casseb
Mar 29, 2011·Analytical Biochemistry·Etienne MalvoisinNadine Vincent
Jun 11, 2010·Indian Journal of Nephrology·M PrakashM Supriya
Sep 2, 2020·International Journal of Molecular Sciences·Ala Litman-ZawadzkaBarbara Mroczko
Aug 29, 2018·BioMed Research International·Emilia LubowickaSławomir Ławicki
Oct 20, 2020·Frontiers in Public Health·Mark Christopher Arokiaraj
Jun 2, 2020·Virus Research·Joel Henrique EllwangerJosé Artur Bogo Chies

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.