PMID: 7545197Apr 1, 1995Paper

Soluble E-selectin and vascular cell adhesion molecule-1 (VCAM-1) in primary biliary cirrhosis

Journal of Hepatology
A G LimT C Northfield

Abstract

E-selectin and vascular cell adhesion molecule-1, important in leucocyte adhesion, have recently been detected in soluble form in the circulation. However, their clinical significance remains unclear. Our aims were to determine whether the levels of these molecules are increased in primary biliary cirrhosis, and to relate these to histological disease stage, biochemical measures of liver damage and to lymphocyte activation. We studied 42 patients with primary biliary cirrhosis, nine with primary sclerosing cholangitis, 14 with alcoholic liver disease and 17 healthy subjects. Circulating E-selectin and vascular cell adhesion molecule-1 levels were measured by enzyme-linked immunosorbent assay. In subgroups of patients with primary biliary cirrhosis, hepatic bile acid uptake and excretory rates and T-cell activation were also determined. Soluble E-selectin and vascular cell adhesion molecule-1 levels were significantly elevated in primary biliary cirrhosis compared to healthy controls. However, there was no difference between primary biliary cirrhosis and other liver disease groups. In primary biliary cirrhosis, both adhesion molecules correlated with disease stage, but differed in their relationships with specific liver function...Continue Reading

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Citations

Jul 31, 2003·Therapeutic Apheresis and Dialysis : Official Peer-reviewed Journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy·Kunio TakegoshiEikichi Okada
May 17, 2008·Liver International : Official Journal of the International Association for the Study of the Liver·Oreste Lo IaconoRafael Bañares
Dec 6, 2000·The Journal of Surgical Research·G Martinez-MierP A Ward
Jul 9, 2004·World Journal of Gastroenterology : WJG·Joanna-W HoSheung-Tat Fan
Mar 31, 2001·The American Journal of Gastroenterology·S BattistaG Molino
Sep 24, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ke QiF William Orr
Nov 28, 2019·Cells·Edith Hintermann, Urs Christen
Aug 19, 2003·European Journal of Heart Failure·Wei-Hsian YinMason Shing Young
Nov 8, 2002·Transplant Infectious Disease : an Official Journal of the Transplantation Society·I H C Vos, D M Briscoe

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