Soluble elastin peptides in cardiovascular homeostasis: Foe or ally

Peptides
Zhenyu Qin

Abstract

Elastin peptides, also known as elastin-derived peptides or elastokines, are soluble polypeptides in blood and tissue. The blood levels of elastin peptides are usually low but can increase during cardiovascular diseases, such as atherosclerosis, aortic aneurysm and diabetes with vascular complications. Generally, elastin peptides are derived from the degradation of insoluble elastic polymers. The biological activities of elastin peptides are bidirectional, e.g., a pro-inflammatory effect on monocyte migration induction vs. a protective effect on vasodilation promotion. However, recent in vivo studies have demonstrated that elastin peptides promote the formation of atherosclerotic plaques in hypercholesterolemic mice and induce hyperglycemia and elevations in plasma lipid levels in fasted mice. More important, the detrimental effects induced by elastin peptides can be largely inhibited by genetic or pharmacological blockade of the elastin receptor complex or by neutralization of an antibody against elastin peptides. These studies indicate new therapeutic strategies for the treatment of cardiovascular diseases by targeting elastin peptide metabolism. Therefore, the goal of this review is to summarize current knowledge about elast...Continue Reading

References

Sep 1, 1989·Journal of Cellular Physiology·M M LongD W Urry
Mar 25, 1988·Science·A HinekS H Barondes
Nov 1, 1988·The Journal of Cell Biology·C H BloodB R Zetter
Jan 15, 1989·The Biochemical Journal·J J ReillyH A Chapman
Apr 1, 1988·Calcified Tissue International·J O HollingerD W Urry
Mar 11, 1988·Biochimica Et Biophysica Acta·M M LongD W Urry
Aug 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·W HornebeckL Robert
Oct 1, 1980·The Journal of Clinical Investigation·R M SeniorR P Mecham
Mar 5, 1981·The New England Journal of Medicine·L B SandbergJ G Leslie
Mar 1, 1995·Journal of Vascular Research·G FauryL Robert
Jul 1, 1994·Cell Adhesion and Communication·A Hinek
Jan 1, 1993·Upsala Journal of Medical Sciences·R TarnawskiM Drózdz
Jul 1, 1997·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·J S LindholtH Fasting
May 22, 1998·Journal of Neuropathology and Experimental Neurology·S JungA Hinek
Jun 9, 2001·The American Journal of Cardiology·Y BernardJ P Bassand
Sep 5, 2002·The Journal of Clinical Investigation·G Matthew LongoB Timothy Baxter
Sep 24, 2002·The Journal of Biological Chemistry·Satsuki MochizukiAleksander Hinek
Nov 19, 2002·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·E PetersenK-A Angquist
Mar 18, 2003·The Journal of Clinical Investigation·Galina K SukhovaGuo-Ping Shi
Jul 31, 2003·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marie Paule Jacob
Jun 12, 2004·The Journal of Biological Chemistry·Yoshiyuki YasudaDieter Brömme
Apr 7, 2005·Biopolymers·Gautier MoroyStéphanie Héry-Huynh
Aug 9, 2005·Pathologie-biologie·Tamas FulopAbdelouahed Khalil
Feb 14, 2006·The Journal of Clinical Investigation·A McGarry HoughtonSteven D Shapiro
Mar 2, 2006·Blood·Stefania FontanaRaffaele Badolato
Sep 26, 2006·Atherosclerosis·G NicoloffA Nikolov

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Citations

Dec 21, 2019·The Biochemical Journal·Pierre-Marie AndraultDieter Brömme
Jul 12, 2019·Matrix Biology : Journal of the International Society for Matrix Biology·Aurélie Le PageTamas Fulop
Jan 29, 2020·International Journal of Biological Macromolecules·Federica BoraldiDaniela Quaglino
Apr 12, 2021·Mechanisms of Ageing and Development·Soo Hyuk KimMingyi Wang

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