Soluble Endoglin (sCD105) as a Novel Biomarker for Detecting Aggressive Prostate Cancer

Anticancer Research
Adriana C VidalJun Gong

Abstract

We have previously found elevated levels of endoglin (CD105) in the prostate cancer (PC) tissue of men with poor prognosis, compared to men with indolent disease. Herein, we examined whether plasma levels of the soluble form of CD105 (sCD105) differ according to the PC grade at diagnosis. We measured sCD105 in 73 subjects with biopsy-confirmed PC at the Durham, North Carolina, Veteran Affairs Health System. The association between sCD105 and intermediate/high-grade PC risk [Gleason Group (GG) 2-5 vs. 1] was examined using regression models. Of 73 men, 27 had low-grade PC and 46 high-grade PC. Higher GG was linked to lower sCD105 (GG1: 6938 pg/ml, GG2-3: 6150 pg/ml, GG4-5: 5554 pg/ml; p=0.012). On multivariable analysis, lower sCD105 was associated with increased high-grade PC risk (ORper 1000 units=1.33, p=0.028). Lower sCD105 levels were associated with intermediate and high-risk PC. Further investigation is warranted in a larger PC cohort.

Citations

Feb 19, 2021·The Journal of Pathology. Clinical Research·Amanda B HesterbergPaula J Hurley
Apr 3, 2021·Developmental Dynamics : an Official Publication of the American Association of Anatomists·John B Pawlak, Gerard C Blobe
May 20, 2021·World Journal of Urology·Francisco PinaNuno Lunet
Jun 27, 2021·Pharmacology & Therapeutics·Maria Adamaki, Vassilios Zoumpourlis

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