Soluble epoxide hydrolase inhibitor promotes immunomodulation to inhibit bone resorption

Journal of Periodontal Research
Marcelo Henrique NapimogaBruce D Hammock

Abstract

Soluble epoxide hydrolase (sEH) is an enzyme in the arachidonate cascade which converts epoxy fatty acids (EpFAs), such as epoxyeicosatrienoic acids (EETs) produced by cytochrome P450 enzymes, to dihydroxy-eicosatrienoic acids. In the last 20 years with the development of inhibitors to sEH it has been possible to increase the levels of EETs and other EpFAs in in vivo models. Recently, studies have shown that EETs play a key role in blocking inflammation in a bone resorption process, but the mechanism is not clear. In the current study we used the sEH inhibitor (1-trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) urea [TPPU]) to investigate the immunomodulatory effects in a mouse periodontitis model. Mice were infected on days 0, 2, and 4 with Aggregatibacter actinomycetemcomitans and divided into groups (n = 6) that were treated orally, daily for 15 days, with 1 mg/kg of TPPU. Then, the mice were killed and their jaws were analyzed for bone resorption using morphometry. Immunoinflammatory markers in the gingival tissue were analyzed by microarray PCR or western blotting. Infected mice treated with TPPU showed lower bone resorption than infected mice without treatment. Interestingly, infected mice showed increased expression ...Continue Reading

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Citations

May 14, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Carlos A Trindade-da-SilvaMarcelo H Napimoga
Aug 13, 2020·Journal of Prosthodontics : Official Journal of the American College of Prosthodontists·Henrique Ballassini AbdallaMarcelo Henrique Napimoga
Dec 31, 2020·International Journal of Molecular Sciences·Jérémie Gautheron, Isabelle Jéru

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