Soluble epoxide hydrolase inhibitors, t-AUCB, downregulated miR-133 in a mouse model of myocardial infarction

Lipids in Health and Disease
Ya-Jun GuiDan-yan Xu

Abstract

It has been demonstrated that soluble epoxide hydrolase inhibitors (sEHIs) are protective against ischemia-induced lethal arrhythmias, but the mechanisms involved are unknown. Previously, we showed that sEHIs might reduce the incidence of ischemic arrhythmias by suppressing microRNA-1 (miR-1) in the myocardium. As miR-1 and miR-133 have the same proarrhythmic effects in the heart, we assumed that the beneficial effects of sEHIs might also relate to the regulation of miR-133. A mouse model of myocardial infarction (MI) was established by ligating the coronary artery. The sEHI t-AUCB (trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid) was administered daily for 7 days before MI. Myocardial infarct size and cardiac function was assessed at 24 h post-MI. The miRNA expression profiles of sham and MI mice treated with or without t-AUCB were determined by microarray and verified by real-time PCR. The incidence of arrhythmias was assessed by in vivo electrophysiologic studies. The mRNA levels of miR-133, its target genes (KCNQ1 [potassium voltage-gated channel subfamily Q member 1] and KCNH2 [potassium voltage-gated channel subfamily H member 2]), and serum response factor (SRF) were measured by real-time PCR; KCNQ1, KCN...Continue Reading

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Citations

Jan 3, 2020·Journal of Cardiovascular Pharmacology·Dongchen ZhouXiaosheng Hu
May 7, 2021·Oxidative Medicine and Cellular Longevity·Md Sayed Ali SheikhIbrahim A M Abdulhabeeb
Dec 29, 2020·Journal of Medicinal Chemistry·Cheng-Peng SunXiao-Chi Ma

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Methods Mentioned

BETA
PCR
transfection

Software Mentioned

TargetScan
SPSS
GraphPad Prism
ImageJ

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