Soluble factors including proteinases released from damaged cells may trigger the wound healing process

Biochemical and Biophysical Research Communications
K TsuboiM Hatanaka

Abstract

The wound healing process is initiated as soon as tissue is injured. Herein, we demonstrate that c-fos and c-myc mRNA transcripts are promptly increased in the wounded tissue in vivo and in vitro. A buffer solution from scraped serum-starved quiescent fibroblasts, when added to resting fibroblasts, caused the increase of c-fos and c-myc mRNA among the indicator cells. Soluble factors contained in the wounding supernatant are responsible for these phenomena and we call them wounding factors. Addition of proteinase inhibitors to the culture medium drastically reduced the c-fos mRNA induction by the wounding factors. Exogenously added trypsin or thrombin mimicked the activity of wounding factors. These results suggest that wounding causes soluble factors including various proteinases to be released from the damaged cells, which trigger the adjacent cells to respond to the injury.

References

Apr 15, 1975·International Journal of Cancer. Journal International Du Cancer·G KimuraJ Summers
Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·L B Chen, J M Buchanan

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Citations

Oct 2, 1998·The EMBO Journal·D LallemandM Yaniv
May 4, 2007·Annual Review of Cell and Developmental Biology·Matthias Schäfer, Sabine Werner
Sep 2, 2014·The Journal of Investigative Dermatology·Christine NeumannPaul L Bigliardi
Apr 17, 2004·The Journal of Investigative Dermatology·Samantha GangnussTimothy E Rayner
Jun 7, 2003·Developmental Cell·Guochun LiRandall S Johnson
May 2, 2002·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Samantha Yates, Timothy E Rayner
Nov 1, 1992·The Journal of Investigative Dermatology·W Y ChenM J Lydon

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