Soluble Fas: a useful marker of inflammation and cardiovascular diseases in uremic patients.

Clinical and Experimental Nephrology
Amgad E El-Agroudy, Ayman El-Baz

Abstract

Inflammation has been associated with atherosclerotic cardiovascular disease (CVD) and anemia in patients with end-stage renal disease (ESRD) which may lead to left ventricular impairment via myocardial hypertrophy and/or ischemia. We therefore sought to investigate serum levels of sFas in uremic patients and its correlation with known markers of inflammation and CVD. The study included 30 patients on hemodialysis, 30 patients with chronic kidney disease (CKD), and 30 normal control subjects. We measured serum levels of sFas, C-reactive protein (CRP), and albumin. We also investigated the association of serum sFas levels with the presence of CVD by echocardiographic assessment before and after 1 year. Levels of sFas were elevated in CKD and ESRD patients compared to controls. sFas levels correlated positively with serum creatinine and negatively with serum albumin. In the dialysis patients, we observed that sFas levels were higher among those with CVD. Compared with baseline, after 1 year of follow-up there was a significant decrease in left ventricular (LV) ejection fraction, increases in LV end-diastolic dimension and LV end-systolic dimension, and myocardial ischemic changes. These results suggest that sFas may be a marker o...Continue Reading

References

Mar 10, 1995·Science·S Nagata, P Golstein
May 19, 1995·Cell·J L Cleveland, J N Ihle
Dec 1, 1994·British Heart Journal·A MatsumoriS Sasayama
Apr 1, 1997·Circulation·G G Neri SerneriR Abbate
Jun 15, 1997·The American Journal of Cardiology·M OkuyamaH Tomoike
Oct 20, 2000·The Journal of Laboratory and Clinical Medicine·M C PerianayagamB L Jaber
Dec 1, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K Kalantar-Zadeh, J D Kopple
Jul 31, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Antonio Santoro, Elena Mancini
Dec 3, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Cheol Whee ParkByung Kee Bang
Dec 3, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Christoph Wanner
Aug 13, 2003·Artificial Organs·Maria Aparecida DalboniMiguel Cendoroglo

❮ Previous
Next ❯

Citations

Apr 26, 2011·Apoptosis : an International Journal on Programmed Cell Death·Kinga Musiał, Danuta Zwolińska
Apr 25, 2012·Cell Stress & Chaperones·Kinga Musiał, Danuta Zwolińska
May 31, 2012·Climacteric : the Journal of the International Menopause Society·I LambrinoudakiE Kouskouni
Aug 18, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kinga Musiał, Danuta Zwolińska

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.