Abstract
Inflammation has been associated with atherosclerotic cardiovascular disease (CVD) and anemia in patients with end-stage renal disease (ESRD) which may lead to left ventricular impairment via myocardial hypertrophy and/or ischemia. We therefore sought to investigate serum levels of sFas in uremic patients and its correlation with known markers of inflammation and CVD. The study included 30 patients on hemodialysis, 30 patients with chronic kidney disease (CKD), and 30 normal control subjects. We measured serum levels of sFas, C-reactive protein (CRP), and albumin. We also investigated the association of serum sFas levels with the presence of CVD by echocardiographic assessment before and after 1 year. Levels of sFas were elevated in CKD and ESRD patients compared to controls. sFas levels correlated positively with serum creatinine and negatively with serum albumin. In the dialysis patients, we observed that sFas levels were higher among those with CVD. Compared with baseline, after 1 year of follow-up there was a significant decrease in left ventricular (LV) ejection fraction, increases in LV end-diastolic dimension and LV end-systolic dimension, and myocardial ischemic changes. These results suggest that sFas may be a marker o...Continue Reading
References
Dec 1, 1978·Circulation·D J SahnA Weyman
Mar 25, 1994·Science·J ChengJ D Mountz
Mar 10, 1995·Science·S Nagata, P Golstein
May 19, 1995·Cell·J L Cleveland, J N Ihle
Dec 1, 1994·British Heart Journal·A MatsumoriS Sasayama
Apr 1, 1997·Circulation·G G Neri SerneriR Abbate
May 1, 1997·Journal of the American College of Cardiology·K NishigakiH Fujiwara
Jun 15, 1997·The American Journal of Cardiology·M OkuyamaH Tomoike
Mar 25, 2000·The New England Journal of Medicine·P M RidkerN Rifai
Oct 20, 2000·The Journal of Laboratory and Clinical Medicine·M C PerianayagamB L Jaber
Dec 1, 2001·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K Kalantar-Zadeh, J D Kopple
Jul 31, 2002·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Antonio Santoro, Elena Mancini
Dec 3, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Cheol Whee ParkByung Kee Bang
Dec 3, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Christoph Wanner
Aug 13, 2003·Artificial Organs·Maria Aparecida DalboniMiguel Cendoroglo
Citations
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May 31, 2012·Climacteric : the Journal of the International Menopause Society·I LambrinoudakiE Kouskouni
Jan 15, 2016·Cytokine·Amira A AdlyRasha Eladawy
Aug 18, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Kinga Musiał, Danuta Zwolińska
Aug 11, 2017·Medicine·Jun ChenWei-Jie Liang
Sep 27, 2018·Toxins·Ligia Maria ClaroRoberto Pécoits-Filho