Soluble Fas (Apo-1) levels in cerebrospinal fluid of multiple sclerosis patients

Journal of Neuroimmunology
Emilio CiusaniAndrea Salmaggi

Abstract

CSF and serum levels of soluble Fas were studied in MS patients, in patients with various neurological diseases and in healthy controls. We did not detect differences in serum sFas levels between MS patients and controls. In CSF, despite sFas levels being similar in all patients studied, a statistically significant correlation between sFas CSF/sFas serum ratio and BBB damage (expressed as albumin CSF/albumin serum ratio) was detected in non-MS neurological disease, but not in MS patients. The normalized ratio (sFas CSF/sFas serum)/(Alb CSF/Alb serum) was significantly increased in MS patients compared to patients with non-inflammatory neurological disease suggesting an intrathecal synthesis of soluble Fas in MS. The percentage of apoptotic mononuclear cells was higher in CSF as compared to peripheral blood; moreover a lower proportion of apoptotic cells was found in CSF of MS patients. The findings lend support to the involvement of sFas in MS pathogenesis and suggest that a lower apoptosis in CSF may be a feature of the disease.

References

Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Nov 17, 1995·Science·T S GriffithT A Ferguson
Feb 2, 1995·Nature·J DheinP H Krammer
Dec 1, 1994·Current Opinion in Immunology·G G SingerA K Abbas
Apr 1, 1993·Current Opinion in Cell Biology·S LeeM B Small
Jul 1, 1995·Brain Pathology·R P Skoff
Oct 1, 1996·The Journal of Experimental Medicine·P DowlingW Husar
Dec 1, 1996·The Journal of Experimental Medicine·S D D'SouzaJ P Antel
Dec 1, 1996·Journal of Neuroimmunology·H IchikawaM Iwata
Apr 1, 1997·Acta Neurologica Scandinavica·S BansilC Rohowsky-Kochan

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Citations

Oct 14, 2005·Journal of Neurology·B SköldenbergL Rosengren
Jan 24, 2004·Brain Research. Brain Research Reviews·Chulhee Choi, Etty N Benveniste
Jan 11, 2002·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·M K Sharief
Oct 3, 1999·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·T SakaiM Osame
Nov 7, 2001·Acta Neurologica Scandinavica·O AktasD Pöhlau
Jan 5, 2002·Journal of Neuroimmunology·Philipp M LenzlingerMaria Cristina Morganti-Kossmann
Jul 6, 2002·Journal of Neuroimmunology·T van VeenB M J Uitdehaag
Aug 13, 2013·Journal of Neuroimmunology·Montserrat MorenoManuel Comabella
Oct 18, 2011·Trends in Neurosciences·Conor Mc GuireGeert van Loo
Aug 1, 2015·Autoimmunity Reviews·Antonella D'AmbrosioPaola Margutti
May 22, 2003·Acta Neurologica Scandinavica·M BilinskaE Gruszka
Jun 5, 2004·Clinical Neurology and Neurosurgery·Darija MahovicSanja Hajnsek
Apr 17, 2012·Autoimmunity Reviews·C ComiU Dianzani
Nov 7, 1999·Journal of Autoimmunity·S Pouly, J P Antel
Oct 31, 2008·Journal of Neuroimmunology·Sanna RintaIrina Elovaara
Mar 1, 2000·Multiple Sclerosis : Clinical and Laboratory Research·Q R HuangG J Stewart
Jul 13, 2000·Cell Death and Differentiation·U WendlingF Zipp
Dec 14, 2001·Neuroreport·B MacchiC Caltagirone
Feb 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mounira DjerbiAlf Grandien
Apr 19, 2012·Arquivos de neuro-psiquiatria·José Augusto Camargo, Paulo Henrique Ferreira Bertolucci

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