Soluble Fas (APO-1/CD95) isoform in adult T-cell leukemia

Leukemia & Lymphoma
S Kamihira, Y Yamada

Abstract

Fas (APO-1/CD95) consists mainly of 2 isoforms, membrane-anchored (mFas) and soluble (sFas), both of which can mediate apoptosis through the Fas-signalling process, not only in normal but also in leukemia T-cells. This suggests that aberrant expression of either mFas or sFas may affect the natural history of T-cell neoplasms, such as adult T-cell leukemia (ATL). For studying the tumor biology related to Fas-mediated apoptosis, ATL cells with up-regulated Fas proteins and its mRNAs are convenient and useful for understanding apoptotic oncology as it occurs in nature. Most attention, so far, has been focused on mFas, and little is known about neoplasms from the viewpoint of sFas. Accordingly, we herein review and discuss the biological and clinical implications of sFas in ATL.

References

Feb 1, 1995·The Journal of Experimental Medicine·J OgasawaraS Nagata
Jul 3, 1997·International Journal of Cancer. Journal International Du Cancer·K SugaharaS Kamihira
Apr 6, 1999·The Journal of Experimental Medicine·T MaedaS Kamihira
Mar 14, 2000·The Journal of Biological Chemistry·M JenkinsJ M McCune

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Citations

Dec 17, 2014·International Journal of Nephrology·Juan José Bollain-Y-GoytiaRafael Herrera-Esparza
Sep 30, 2005·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·M K KashyapS K Upadhyaya
Apr 10, 2013·Artificial Organs·Miguel Angelo GóesMiguel Cendoroglo
Feb 4, 2014·Einstein·Ilana Levy KorkesMiguel Cendoroglo Neto

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