Soluble Fas/APO-1 in tumor cells: a potential regulator of apoptosis?

Cancer Letters
L B Owen-SchaubD P Bartos

Abstract

Fas/APO-1, a member of the NGF/TNF receptor superfamily expressed on the cell-surface of normal and malignant cells, is known to induce cell death by apoptosis. In the present study, we have investigated Fas/APO-1 gene defects in a human osteosarcoma cell line resistant to the apoptosis-inducing effects of anti-Fas. cDNA cloning and sequencing revealed that these cells contained both 'authentic' and mutant Fas/APO-1 containing a 63 base pair in-frame deletion spanning the transmembrane domain, designated DFas/APO-1. Direct evidence for the existence of a soluble Fas/APO-1 protein was obtained by immunoprecipitation and Western blotting. Taken together with prior studies demonstrating a role for Fas/APO-1 and Fas ligand, respectively, in tumor target cell killing by cytotoxic T-lymphocytes, production of soluble Fas/APO-1 might have significant implications in malignant disease pathogenesis.

References

Jun 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·G NunezR Dalla-Favera
Oct 1, 1993·Journal of Immunotherapy with Emphasis on Tumor Immunology : Official Journal of the Society for Biological Therapy·L B Owen-SchaubR J Ford
May 10, 1994·Proceedings of the National Academy of Sciences of the United States of America·S T JuA Marshak-Rothstein
May 24, 1994·Proceedings of the National Academy of Sciences of the United States of America·S HanabuchiK Okumura
Oct 1, 1994·European Journal of Immunology·M GrellP Scheurich
Jan 1, 1993·The Journal of Experimental Medicine·E RouvierP Golstein
Mar 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·M AdachiS Nagata
Aug 1, 1993·The Journal of Experimental Medicine·J WuJ D Mountz
Oct 1, 1994·International Immunology·T TakahashiS Nagata
May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J H RussellR Wang

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Citations

Jul 29, 1997·International Journal of Cancer. Journal International Du Cancer·J FellenbergK M Debatin
Jan 1, 1997·Arthritis and Rheumatism·T HasunumaK Nishioka
Aug 24, 2001·Brain Tumor Pathology·M IchinoseK Tabuchi
Sep 10, 2005·Apoptosis : an International Journal on Programmed Cell Death·Z Kondera-AnaszJ Sikora
Dec 4, 2003·Mutation Research·Elza T Sakamoto-HojoGeraldo A S Passos
Feb 2, 2000·Urology·N NonomuraA Okuyama
Mar 19, 1999·Immunology Today·J O'ConnellF Shanahan
Jun 1, 2000·Experimental Gerontology·L A Cubano, M L Lewis
Jun 22, 2001·Urologic Oncology·F G.E. PeraboS C. Müller
Mar 24, 2004·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Takuya OkamotoNobuyuki Terada
Apr 16, 1998·The Journal of Clinical Investigation·Y NambuD G Beer
Dec 24, 2003·BMC Cancer·Arslan AkhmedkhanovPaolo Toniolo
Jul 10, 2009·Yi chuan = Hereditas·Xiu-Feng ZhangYing Luo
Jul 2, 1998·Clinical and Experimental Immunology·S JodoT Koike
Nov 14, 2013·Cancer Chemotherapy and Pharmacology·Hidenari NagaiYasukiyo Sumino
Sep 26, 2002·World Journal of Surgery·Shyr-Ming Sheen-ChenBruno Jawan
Jan 1, 2006·Women's Health·Angiolo GadducciAndrea Riccardo Genazzani
Jan 5, 2002·Journal of Neuroimmunology·Philipp M LenzlingerMaria Cristina Morganti-Kossmann
Mar 11, 2005·Expert Opinion on Therapeutic Targets·Sören T Eichhorst
Jul 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M NagaoH Nakano
Jul 4, 2008·Critical Reviews in Oncology/hematology·Angiolo GadducciAndrea Riccardo Genazzani
Sep 11, 2007·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Yaxi MaXing Xie
May 29, 2003·Journal of Surgical Oncology·Lorenzo PignataroMassimiliano Marco Corsi
Apr 20, 2004·Journal of Cellular Physiology·William F HolmesKenneth J Soprano
May 17, 2007·International Journal of Immunogenetics·W MahfoudhL Chouchane
Aug 8, 2006·Ophthalmology·Rohit VarmaUNKNOWN Los Angeles Latino Eye Study Group
Jul 29, 1998·The Journal of Urology·Y MizutaniB Bonavida
Dec 6, 2005·Journal of Neuroimmunology·Farideh SabriBirgit Sköldenberg
Sep 16, 2006·Cellular & Molecular Biology Letters·Indrajit ChowdhuryGanapathy K Bhat
Jul 27, 1999·Gynecologic Oncology·R L BaldwinB Y Karlan
Oct 20, 2000·The Journal of Laboratory and Clinical Medicine·M C PerianayagamB L Jaber
Dec 24, 1997·Leukemia & Lymphoma·K Clodi, A Younes
Jul 17, 1999·British Journal of Cancer·M KimuraK Takahashi

❮ Previous
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