Abstract
Soluble fibre modulates airway inflammation in animal models. The aim of this study was to investigate the effects of soluble fibre supplementation, with and without a probiotic, on plasma short chain fatty acids (SCFA), airway inflammation, asthma control and gut microbiome in adults with asthma. A randomised, double-blinded, placebo controlled 3-way cross-over trial in 17 subjects with stable asthma at the Hunter Medical Research Institute, Newcastle, Australia. Subjects received 3 × 7 day oral interventions in random order; soluble fibre (inulin 12 g/day), soluble fibre + probiotic (inulin 12 g/day + multi-strain probiotic >25 billion CFU) and placebo. Plasma SCFA, sputum cell counts and inflammatory gene expression, asthma control gut microbiota, adverse events including gastrointestinal symptoms were measured. There was no difference in change in total plasma SCFA levels (μmol/L) in the placebo versus soluble fibre (Δmedian [95% CI] 16·3 [-16·9, 49·5], p = 0·335) or soluble fibre+probiotic (18·7 [-14·5, 51·9], p = 0·325) group. Following the soluble fibre intervention there was an improvement in the asthma control questionnaire (ACQ6) (∆median (IQR) -0·35 (-0·5, -0·13), p = 0·006), sputum %eosinophils decreased (-1.0 (-2·5...Continue Reading
Citations
Feb 20, 2020·Beneficial Microbes·K S SwansonJ L Slavin
Jun 20, 2020·FEMS Microbiology Reviews·Francesca De FilippisDanilo Ercolini
Jul 30, 2020·The Biochemical Journal·Riddhi Trivedi, Kalyani Barve
Dec 20, 2019·Expert Review of Respiratory Medicine·Meghan Althoff, Fernando Holguin
Aug 8, 2020·Allergy·Charlotte A AlemaoPhilip M Hansbro
Dec 29, 2020·Molecular Nutrition & Food Research·Mensiena B G KiewietPaul de Vos
Nov 20, 2020·Nature Communications·Kate L BowermanPhilip M Hansbro
Feb 23, 2020·Immunity·Weronika BarcikB Brett Finlay
Apr 19, 2020·Paediatric Respiratory Reviews·Rebecca F McLoughlinLisa G Wood
Apr 3, 2021·Frontiers in Immunology·Petra I PfefferleHolger Garn
Apr 9, 2021·Respirology : Official Journal of the Asian Pacific Society of Respirology·Lisa G Wood
May 1, 2021·Respiratory Research·Claire HealySuzanne M Cloonan
May 1, 2021·International Journal of Molecular Sciences·Eva Maria SturmGunther Marsche
May 21, 2021·Frontiers in Immunology·Verena M MerkThomas Brunner
Jul 2, 2021·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·Bronwyn S BerthonLisa G Wood
Sep 11, 2021·The Journal of Allergy and Clinical Immunology. in Practice·Meghan D AlthoffSunita Sharma
Sep 30, 2021·European Journal of Clinical Nutrition·Amrita Vijay, Ana M Valdes
Oct 7, 2021·Microbiology Spectrum·Ailing LiuZhihong Sun
Oct 7, 2021·Critical Reviews in Food Science and Nutrition·Yinghan ChanKamal Dua
Sep 21, 2021·Advances in Nutrition·Lily M WilliamsLisa G Wood
Nov 28, 2021·Nutrients·Roos E M VerstegenLinette E M Willemsen