Soluble fibrinogen modulates neutrophil functionality through the activation of an extracellular signal-regulated kinase-dependent pathway

The Journal of Immunology : Official Journal of the American Association of Immunologists
C RubelM S Palermo

Abstract

The integrin family not only mediates the recruitment of polymorphonuclear leukocytes (PMN) to sites of inflammation but also regulates several effector functions by binding to specific ligands. We have recently demonstrated that soluble fibrinogen (sFbg) is able to trigger an activating signal in PMN through an integrin-dependent mechanism. This activation results in degranulation, phagocytosis enhancement, and apoptosis delay. The aim of the present work was to further elucidate the molecular events that follow sFbg interaction with CD11b in human PMN, and the participation of this signaling pathway in the regulation of neutrophil functionality. We demonstrate that sFbg triggers a cascade of intracellular signals that lead to focal adhesion kinase and extracellular signal-regulated kinase 1/2 tyrosine phosphorylation. The activation of this mitogen-activated protein kinase pathway plays a central role in the sFbg modulation of secondary granule degranulation, Ab-dependent phagocytosis, and apoptosis. However, fibrinogen-induced secretory vesicle degranulation occurs independently of the signaling transduction pathways investigated herein. In the context of an inflammatory process, the intracellular signal pathway activated by...Continue Reading

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Citations

Sep 10, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Issam HarfiEric Sariban
Jul 28, 2019·Current Opinion in Hematology·Oscar Negrón, Matthew J Flick
Aug 1, 2007·Journal of Thrombosis and Haemostasis : JTH·J L DegenJ D Goguen
Jun 29, 2006·Cellular Microbiology·Mark P SimonsMichael A Apicella
Nov 27, 2004·Experimental Biology and Medicine·Matthew J FlickJay L Degen
Jul 28, 2009·Journal of Thrombosis and Haemostasis : JTH·J K RyuK Akassoglou
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Issam HarfiEric Sariban
Nov 14, 2003·American Journal of Physiology. Cell Physiology·John MeshkiSatya P Kunapuli
Apr 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Markus P RadsakHansjörg Schild
Jun 9, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Gabriela C FernándezMarina S Palermo
Dec 22, 2015·Cellular & Molecular Immunology·Zhou ZhouBin Gao
Apr 4, 2021·International Journal of Molecular Sciences·Anne-Marije HulshofHugo Ten Cate
Apr 16, 2021·International Immunopharmacology·M Fathimath MuneesaYashodhar P Bhandary
May 16, 2021·Journal of Hepatology·Matthew J McConnellYasuko Iwakiri
Dec 23, 2003·Immunology Letters·Alejandro Ortiz-Stern, Carlos Rosales
Oct 19, 2021·Hepatology Communications·Matthew J McConnellYasuko Iwakiri

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