Soluble form of P-selectin in plasma is elevated in acute lung injury

American Journal of Respiratory and Critical Care Medicine
F SakamakiM Katayama

Abstract

A number of adhesion molecules on neutrophils and the pulmonary capillary endothelium mediate the neutrophil accumulation in the lungs at the onset of adult respiratory distress syndrome or acute lung injury (ALI). P-selectin, located on both vascular endothelial cells and platelets, has been shown to be one of these neutrophil-endothelial cell adhesion molecules. In this study, we measured the soluble form of P-selectin in plasma (PPS) from 19 patients (surviving, 11; deceased, 8) with ALI due to various causes and assessed the clinical significance of this measurement. Twelve healthy subjects and 29 patients with other pulmonary diseases, including idiopathic pulmonary fibrosis (IPF) (n = 8), sarcoidosis (n = 5), pneumonia (n = 8), and sepsis without ALI (n = 8) were also studied for comparison. PPS in patients with ALI (474.5 +/- 366.8 ng/ml, mean +/- SD) were significantly higher than those in control subjects (98.8 +/- 39.7, p < 0.01) and in patients with IPF (210.4 +/- 76.6, p < 0.05), sarcoidosis (135.2 +/- 71.5, p < 0.05), pneumonia (225.3 +/- 81.0, p < 0.05), and sepsis without ALI (271.8 +/- 46.5, p < 0.05). There was no significant difference in PPS levels between seven patients with and 12 patients without multiple ...Continue Reading

Citations

Feb 19, 2004·Advanced Drug Delivery Reviews·Carsten EhrhardtUdo Bakowsky
Jan 1, 1997·Archives of Gerontology and Geriatrics·A SuehiroE Kakishita
Jul 10, 1999·Journal of the American College of Cardiology·J E HollanderF S Shofer
May 26, 1999·Infectious Disease Clinics of North America·C Parent, P Q Eichacker
May 15, 2003·Shock·Monika GraningerBernd Jilma
May 18, 1999·Archives of Disease in Childhood·P B BainesC A Hart
Jan 1, 1997·Annual Review of Medicine·K G Connelly, J E Repine
Mar 2, 1999·American Journal of Respiratory and Critical Care Medicine·B JilmaO F Wagner
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·V NewmanL G Dobbs
Jul 21, 2000·American Journal of Respiratory and Critical Care Medicine·K M KerrK M Moser
Aug 17, 1999·The Journal of Clinical Investigation·W M KueblerJ Bhattacharya
Jul 1, 2009·Journal of Pediatric Neurosciences·Soad M JaberSherifa A Hamed
Oct 26, 2013·Critical Care Medicine·Matty L TerpstraA B Johan Groeneveld
Dec 19, 2014·Journal of Intensive Care·Seitaro Fujishima
Jul 5, 2005·Expert Opinion on Investigational Drugs·S A Mousa
Mar 17, 2016·Disease Markers·Raiko BlondonnetMatthieu Jabaudon
Mar 4, 2009·Chest·Steven M KawutUNKNOWN Lung Transplant Outcomes Group
Jul 29, 1999·Chest·G A ZimmermanM S Topham
Jun 27, 2014·Thrombosis and Haemostasis·Sacha F de StoppelaarTom van der Poll
Oct 8, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Mark L BarrUNKNOWN ISHLT Working Group on Primary Lung Graft Dysfunction
Mar 14, 2009·Journal of Intensive Care Medicine·Joseph E LevittMichael A Matthay
Oct 21, 2017·International Journal of Molecular Sciences·Elisabetta GrecoGiuseppe Montrucchio
Aug 22, 2017·Military Medical Research·Wujian Xu, Yong Song
Feb 12, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Ian del CondeNeal S Kleiman
Jul 1, 2011·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Patrick PaulusKai Zacharowski
May 31, 2014·Expert Review of Respiratory Medicine·James M WalterLorraine B Ware
Aug 3, 2019·The European Respiratory Journal·Claire F McGroderAnna J Podolanczuk
Jul 20, 2004·Intensive Care Medicine·S E OrfanosC Roussos
Jun 7, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rick KapurJohn W Semple

❮ Previous
Next ❯

Related Concepts

Related Feeds

American Thoracic Association Journals

Discover the latest respiratory research published by the journals from the American Thoracic Society.

© 2021 Meta ULC. All rights reserved