PMID: 8605703Mar 1, 1996Paper

Soluble forms of P-selectin and intercellular adhesion molecule-3 in synovial fluids

Clinical Immunology and Immunopathology
S HosakaA E Koch

Abstract

A number of adhesion molecules have been identified in synovial tissues of patients with rheumatoid arthritis (RA). Some of them are upregulated and may play an important role in the inflammatory processes of the diseased joint. In addition to synovial tissue cell surface expression, synovial fluids contain soluble forms of many adhesion molecules, such as intercellular adhesion molecule-1, E-selectin (sE-selectin), and L-selectin. In this study, we investigated the expression of soluble P-selectin (sP-selectin) and intercellular adhesion molecule-3 (sICAM-3) in synovial fluids from patients with RA, osteoarthritis (OA), and other forms of arthritis. sP-selectin and sICAM-3 levels in RA synovial fluids were significantly increased compared to those in OA. The levels of sP-selectin++ in synovial fluids correlated with sICAM-3 and sE-selectin in synovial fluids. The levels of sICAM-3 in synovial fluids correlated with synovial fluid leukocyte counts and erythrocyte sedimentation rate. In vitro, synovial fluid mononuclear cells produced sICAM-3 spontaneously. Elevated levels of sP-selectin and sICAM-3 in RA synovial fluids compared to OA may indicate inflammatory interactions between endothelial cells, leukocytes, and other synovi...Continue Reading

Citations

Oct 7, 2005·Arthritis Research & Therapy·Jeffrey H RuthDaniel C Bullard
Jun 29, 2010·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tao ChengXian-Long Zhang
Jul 23, 2015·Angiogenesis·Hatem A ElshabrawyShiva Shahrara
Dec 29, 2005·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Teresa K Tarrant, Dhavalkumar D Patel
Nov 5, 1997·Clinical Immunology and Immunopathology·J M WoodsA E Koch
May 23, 2007·Molecular Medicine·Christopher J EdwardsDebra D Pittman
Jan 5, 2007·Journal of Medicinal Chemistry·Neelu KailaQin Wang
May 1, 1997·Clinical and Diagnostic Laboratory Immunology·P P Sfikakis, G C Tsokos

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