Soluble gas exchange in the pulmonary airways of sheep

Journal of Applied Physiology
Carmel SchimmelMichael P Hlastala

Abstract

We studied the airway gas exchange properties of five inert gases with different blood solubilities in the lungs of anesthetized sheep. Animals were ventilated through a bifurcated endobronchial tube to allow independent ventilation and collection of exhaled gases from each lung. An aortic pouch at the origin of the bronchial artery was created to control perfusion and enable infusion of a solution of inert gases into the bronchial circulation. Occlusion of the left pulmonary artery prevented pulmonary perfusion of that lung so that gas exchange occurred predominantly via the bronchial circulation. Excretion from the bronchial circulation (defined as the partial pressure of gas in exhaled gas divided by the partial pressure of gas in bronchial arterial blood) increased with increasing gas solubility (ranging from a mean of 4.2 x 10(-5) for SF6 to 4.8 x 10(-2) for ether) and increasing bronchial blood flow. Excretion was inversely affected by molecular weight (MW), demonstrating a dependence on diffusion. Excretions of the higher MW gases, halothane (MW = 194) and SF6 (MW = 146), were depressed relative to excretion of the lower MW gases ethane, cyclopropane, and ether (MW = 30, 42, 74, respectively). All results were consistent...Continue Reading

References

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Citations

Mar 26, 2010·Annals of Biomedical Engineering·Joseph C Anderson, Michael P Hlastala
Mar 23, 2012·Animal : an International Journal of Animal Bioscience·C MartinC S Pinares-Patiño
Jan 9, 2016·Drug Discovery Today. Disease Models·Jarred R MondoñedoDavid W Kaczka
Jan 18, 2006·Pulmonary Pharmacology & Therapeutics·Joseph C Anderson, Michael P Hlastala
Nov 12, 2005·Journal of Applied Physiology·Joseph C AndersonMichael P Hlastala
May 21, 2016·Journal of Applied Physiology·Michael P Hlastala, Joseph C Anderson
May 21, 2019·Journal of Engineering and Science in Medical Diagnostics and Therapy·Jarred R MondoñedoDavid W Kaczka
Jan 12, 2013·Journal of Applied Physiology·Michael P HlastalaJoseph C Anderson
Apr 17, 2019·Journal of Applied Physiology·Joseph C Anderson, Michael P Hlastala

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