PMID: 5257968May 1, 1969Paper

Soluble hepatic delta-aminolevulinic acid synthetase: end-product inhibition of the partially purified enzyme

Proceedings of the National Academy of Sciences of the United States of America
P L SholnickH S Marver

Abstract

The present study confirms the existence of hepatic delta-aminolevulinic acid synthetase in the cytosol of the liver, suggests that this enzyme may be in transit to the mitochondria, and defines some of the characteristics of the partially purified enzyme. The substrate and cofactor requirements are similar to those of mitochondrial delta-aminolevulinic acid synthetase. Heme strongly inhibits the partially purified enzyme. A number of proteins that bind heme block this inhibition, which explains previous failures to demonstrate heme inhibition in crude systems. End-product inhibition of delta-aminolevulinic acid synthetase in the mitochondria may play an important role in the regulation of heme biosynthesis in eukaryotic cells.

References

Dec 30, 1968·Biochemical and Biophysical Research Communications·H S MarverH Schützel
Oct 29, 1968·Biochimica Et Biophysica Acta·J N Loeb, B G Hubby
Nov 1, 1957·Biochimica Et Biophysica Acta·R F LABBE, G NISHIDA
Jan 18, 1965·Biochemical and Biophysical Research Communications·D KARIBIAN, I M LONDON
Apr 1, 1965·Proceedings of the National Academy of Sciences of the United States of America·D P TSCHUDYM RECHCIGL

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Citations

Dec 1, 1977·Biochemical Genetics·D A Brenner, J R Bloomer
Nov 1, 1971·Proceedings of the National Academy of Sciences of the United States of America·H L BonkowskyC J Watson
Apr 1, 1978·British Journal of Pharmacology·A GoldbergG G Thompson
Sep 1, 1976·Archives of Biochemistry and Biophysics·D M Bissell, L E Hammaker
Aug 1, 1970·Archives of Biochemistry and Biophysics·D S Beattie, R N Stuchell
Jun 1, 1971·Archives of Biochemistry and Biophysics·Y K Ho, J Lascelles
Jul 1, 1978·Archives of Biochemistry and Biophysics·J R PaternitiD S Beattie
Aug 11, 1970·Biochemical and Biophysical Research Communications·E HasegawaT R Tephly
Nov 25, 1970·Biochemical and Biophysical Research Communications·M S Jones, O T Jones
Feb 1, 1971·Metabolism: Clinical and Experimental·T R TephlyJ Baron
Dec 24, 1970·Biochemical and Biophysical Research Communications·J D Ross, U Muller-Eberhard
Jul 1, 1971·Archives of Biochemistry and Biophysics·F L Margolis
Jan 1, 1972·Archives of Biochemistry and Biophysics·R J PorraA M Tennick
Nov 1, 1970·Archives of Biochemistry and Biophysics·J J Hutton, S R Gross
Aug 15, 1983·Biochemical Pharmacology·G E MillerF E Greene
Jan 1, 1971·CRC Critical Reviews in Clinical Laboratory Sciences·J PindyckR D Levere
Sep 1, 1990·Journal of Gastroenterology and Hepatology·J M RankJ R Bloomer
Nov 25, 2004·Clinics in Liver Disease·Y V ScarlettJ R Bloomer

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