PMID: 9550332Apr 29, 1998Paper

Soluble HLA class I and class II antigens in patients with multiple sclerosis

Tissue Antigens
M OttH Grosse-Wilde

Abstract

Soluble HLA class I (sHLA-I) and soluble HLA class II (sHLA-II) antigen levels during different stages of disease were investigated in paired serum and cerebrospinal fluid (CSF) samples from 37 patients with multiple sclerosis (MS) using ELISA and Western blot analysis. Soluble HLA-II antigens in the serum of untreated patients with the relapsing-remitting type of MS (RRMS) were found to be significantly elevated in acute relapse as compared to values obtained from patients under steroid treatment, in remission or healthy controls. No significant differences in circulating sHLA-I levels could be detected. In contrast, a trend towards increased intrathecal production of sHLA-I molecules in the CSF was observed in untreated RRMS patients in acute relapse, whereas the levels of soluble HLA-II antigens in the CSF were below the detection limit of the ELISA method. Our observations underline the presence of systemic immune activation in MS patients, as reflected in elevated serum sHLA-II antigen levels, and reveal a dichotomy between sHLA class I and II antigen production in the peripheral blood versus CSF in acute MS. Serial measurements of sHLA-II antigen levels might represent a non-invasive method to assess disease activity in M...Continue Reading

References

Jan 1, 1992·Journal of Neuroimmunology·J C Alvarez-CermeñoP González-Porqué
Apr 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·G W HoffmannM D Grant
Apr 1, 1991·Transplantation·N ZavazavaW Müller-Ruchholtz
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·P BriataJ S Lee
May 1, 1986·The Journal of Experimental Medicine·M S Krangel
Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Jan 1, 1993·European Neurology·J C Alvarez-CermeñoP González-Porqué

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Citations

Jul 15, 2018·Acta neurologica Belgica·Alia SaberiSamaneh Kazemi
Oct 14, 2000·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·I AthanassakisS Vassiliadis
Mar 11, 2004·Tissue Antigens·A HeiligenhausH Grosse-Wilde
Apr 25, 2020·Brain Sciences·Giovanni SchepiciEmanuela Mazzon
May 13, 1999·Human Immunology·D AultmanJ McDonald

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