Soluble HLA class I molecules exert differentiated influence on renal graft condition

Transplantation Proceedings
A ChudykS Giedrys-Kalemba

Abstract

The function of soluble HLA (sHLA) antigens in the process of immunoregulation and especially in graft tolerance versus rejection has not yet been established. It has been suggested that donor-derived sHLA may exert an immunotolerant influence on the graft. We sought to determine the role of sHLA class I in kidney graft survival by evaluating the influence of these molecules on allotypic lymphocytotoxic antibodies and the concentration of gamma interferon (INF-gamma). Analysis of sHLA was performed indirectly utilizing their ability to inhibit lymphocytotoxic reaction dependent on complement activation. To demonstrate the inhibitory properties of sHLA, we modified the NIH microcytotoxic test. Furthermore, we determined the concentration of INF-gamma in all sera samples for comparison with the intensity of the cytotoxic test. The comparison of the intensity of cytotoxic test inhibition with the concentration of INF-gamma revealed that high concentrations of this cytokine were associated with stronger inhibition of the cytotoxic test, thus with higher concentrations of sHLA class I molecules in recipient sera. We observed that high concentrations of sHLA class I molecules in recipient sera significantly inhibited cytotoxic reacti...Continue Reading

References

Jan 1, 1977·Transplantation·S FerroneR A Reisfeld
Jan 1, 1994·Journal of Clinical Laboratory Analysis·N ZavazavaW Müller-Ruchholtz
May 1, 1993·Annals of Surgery·V K RhynesM C Mancini
Jul 17, 1999·Human Immunology·A MinguelaM R Alvarez-López
Apr 25, 2003·Transplant International : Official Journal of the European Society for Organ Transplantation·Anna MhoyanHaval Shirwan
Oct 28, 2003·European Journal of Immunology·Grazia Maria SpaggiariAlessandro Poggi

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Citations

Feb 19, 2016·Journal of Alzheimer's Disease : JAD·José A LuchsingerEmilia Bagiella

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