PMID: 11923036Mar 30, 2002Paper

Soluble intercellular adhesion molecule-1 and long-term risk of acute coronary events in patients with chronic coronary heart disease. Data from the Bezafibrate Infarction Prevention (BIP) Study

Journal of the American College of Cardiology
Moti HaimSolomon Behar

Abstract

The goal of this study was to assess soluble intercellular adhesion molecule-1 (sICAM-1) level as a predictor of future acute coronary events in patients with chronic coronary heart disease (CHD). Increased sICAM-1 concentration has been shown to be associated with the incidence of CHD in healthy persons. Its significance in patients with CHD has been scarcely investigated. We designed a prospective, nested case-control study. Sera were collected from patients with CHD enrolled in a secondary prevention trial that evaluated the efficacy of bezafibrate in reducing coronary events. We measured baseline sICAM-1 concentration in the sera of patients who developed subsequent cardiovascular events (cases: n = 136) during follow-up (mean: 6.2 years) and in age- and gender-matched controls (without events: n = 136). Baseline serum concentrations of sICAM-1 were significantly higher in cases versus controls (375 vs. 350 ng/ml; p < 0.05). Each 100 ng/ml increase in sICAM-1 concentration was associated with 1.27 (95% confidence interval [CI]: 1.00 to 1.63) higher relative odds of coronary events. Soluble ICAM-1 concentration in the highest quartile (>394 ng/ml) was associated with significantly higher odds of coronary events (compared wit...Continue Reading

References

Jan 23, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Jan 30, 1992·The New England Journal of Medicine·V FusterJ H Chesebro
Apr 3, 1997·The New England Journal of Medicine·P M RidkerC H Hennekens
Jan 14, 1999·The New England Journal of Medicine·R Ross
Jun 22, 1999·The New England Journal of Medicine·G D Sloop
Dec 10, 1999·Journal of the American College of Cardiology·M Porsch-OezçueruemezC Luley
Jul 6, 2000·Circulation·UNKNOWN Bezafibrate Infarction Prevention (BIP) study
Oct 12, 2000·Journal of the American College of Cardiology·N T MulvihillM Walsh
Feb 7, 2001·Circulation·P M RidkerN Rifai
Apr 3, 2001·Circulation·P Libby, D I Simon
Jun 8, 2001·Atherosclerosis·C ParkerJ E Freedman
Jun 9, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·K YanoR P Tracy

❮ Previous
Next ❯

Citations

Mar 1, 2006·International Journal of Cardiology·David TanneSolomon Behar
Nov 13, 2003·Atherosclerosis·Stefan BlankenbergLaurence Tiret
Jan 20, 2004·International Journal of Cardiology·Moti HaimUNKNOWN Bezafibrate Infarction Prevention Study Group
Oct 3, 2003·Journal of the American College of Cardiology·Michael E WidlanskyJoseph A Vita
Oct 9, 2002·Journal of Internal Medicine·G J Blake, P M Ridker
Mar 10, 2004·The British Journal of Nutrition·Peter SandersonJoseph A Vita
Mar 1, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Erik M StuvelingDick de Zeeuw
Dec 22, 2006·Occupational and Environmental Medicine·M S O'NeillJ Schwartz
Sep 20, 2005·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·David KarásekDalibor Novotný
May 23, 2015·Thrombosis and Haemostasis·Matthias HokeGeorg Goliasch
Jan 24, 2007·Psychophysiology·Shamini JainJoel E Dimsdale
Mar 22, 2008·Journal of the American College of Cardiology·Mary F WalterUNKNOWN PREVENT Investigators
Oct 18, 2006·Critical Reviews in Clinical Laboratory Sciences·Susann ErikssonKim Pettersson
Feb 27, 2010·Scandinavian Cardiovascular Journal : SCJ·Ole EschenErik Berg Schmidt
Apr 15, 2017·Environmental Research·Shohreh F FarzanMargaret R Karagas
Dec 13, 2005·Experimental Neurology·J MiklossyP L McGeer
Oct 14, 2004·Journal of Hypertension·Roland von KänelJoel E Dimsdale
Aug 15, 2002·Circulation·Christie M Ballantyne, Mark L Entman
Jun 24, 2006·Journal of Cardiovascular Pharmacology·Peter OchodnickyDick de Zeeuw
Mar 1, 2014·Circulation Research·Hans J de HaasJagat Narula
Aug 5, 2017·Journal of Cardiovascular Pharmacology·Thomas P JohnstonAmirhossein Sahebkar
Mar 25, 2009·Pharmacological Reports : PR·Charlotte Lawson, Sabine Wolf
Feb 18, 2003·Current Opinion in Nephrology and Hypertension·Agostino Virdis, Ernesto L Schiffrin
Oct 18, 2016·Psychosomatic Medicine·Christopher M CelanoJeff C Huffman
Apr 20, 2011·Periodontology 2000·Xiang Ying OuyangShuang Ying Zhou

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.