Abstract
We measured soluble intercellular adhesion molecule-1 (sICAM-1) in the serum and cerebrospinal fluid (CSF) of 35 clinically active relapsing-remitting (RR) multiple sclerosis (MS) patients who underwent both lumbar puncture and gadopentetate dimeglumine (Gd-DTPA)-enhanced MRI within an interval of 1 week, and of 30 neurological controls of whom 17 had noninflammatory neurologic diseases (NIND), 8 bacterial meningitis (BM), and 5 AIDS dementia complex (ADC). Thirteen of the MS patients assumed corticosteroids at the time of the study. While sICAM-1 serum levels were highest in the BM group (p < 0.005), untreated MS patients showed levels higher (p < 0.05) than treated MS and NIND, but similar to ADC. Moreover, the untreated MS group had CSF/serum sICAM-1:CSF/serum albumin (sICAM-1 index) values higher than the treated group (p < 0.01), NIND (p < 0.005), and BM (p < 0.05); high sICAM-1 index was found also in ADC. Untreated MS patients with one or more Gd-DTPA-enhancing MRI lesions (Gd-positive) had higher mean values of CSF/serum albumin ratio (QAlbumin) and CSF mononuclear cells compared to patients without such lesions (Gd-negative). In the untreated Gd-negative patients, sICAM-1 serum levels were higher (p < 0.05) than those ...Continue Reading
Citations
Oct 19, 1999·Medical Oncology·B P O'NeillM Rodriguez
Jan 13, 2005·Journal of Neurology·Maria Pia AmatoUNKNOWN Evaluation of the EDMUS system (EVALUED) Study Group
Feb 25, 2005·Journal of Neurology·Göksemin AcarEgemen Idiman
Jun 20, 2001·Journal of the Neurological Sciences·C AvolioM Trojano
Jul 22, 1998·Journal of Neuroimmunology·P LewczukH Tumani
Aug 4, 1998·Journal of Neuroimmunology·A A PetersenG L Vejlsgaard
Sep 10, 2003·Nihon rinsho. Japanese journal of clinical medicine·Hirofumi Ochi
Apr 30, 2003·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Munire KilincRana Karabudak
Nov 9, 2005·Critical Care Medicine·François G BrivetBruno Mégarbane
Dec 20, 2007·American Journal of Therapeutics·Domenico Fiore
Mar 10, 2005·Neuroimmunomodulation·Holger KronigNorbert Muller
Jul 1, 2009·Journal of Pediatric Neurosciences·Soad M JaberSherifa A Hamed
Mar 4, 2014·Internal Medicine·Ryo Tomioka, Makoto Matsui
Feb 3, 2007·Neurobiology of Disease·Henrietta M NielsenSabina M Janciauskiene
May 30, 2012·Neuroscience Letters·Louise A HurstM Nicola Woodroofe
Sep 20, 2008·FEMS Immunology and Medical Microbiology·Daniel Grenier, Charles Bodet
Apr 16, 1998·Glia·P D Lyons, E N Benveniste
Nov 8, 2006·Multiple Sclerosis : Clinical and Laboratory Research·C A Braun HashemiO J Kolar
Oct 8, 1998·Multiple Sclerosis : Clinical and Laboratory Research·P RieckmannK Felgenhauer
Oct 8, 1998·Multiple Sclerosis : Clinical and Laboratory Research·M TrojanoP Livrea
Dec 3, 1999·Brain : a Journal of Neurology·I DuránX Montalban
Nov 23, 2019·Practical Neurology·Vivien LiJalesh N Panicker
Jul 28, 2015·International Journal of Molecular Sciences·Alexandra PintérTimo Siepmann
May 15, 2003·Cell Communication & Adhesion·Maurizio GiorelliMaria Trojano
Apr 9, 1998·Multiple Sclerosis : Clinical and Laboratory Research·M TrojanoP Livrea