PMID: 9526607Apr 4, 1998Paper

Soluble intercellular adhesion molecule-1 serum profile in physiologic and preeclamptic pregnancy

American Journal of Reproductive Immunology : AJRI
L AiroldiM Vignali

Abstract

The aim of this study was to determine serum levels of soluble intercellular adhesion molecule (sICAM)-1, an adhesion receptor that mediates interactions with the immune system, in physiologic and preeclamptic pregnancies. Moreover, we evaluated whether the release of sICAM-1 during pregnancy correlated to plasma fibronectin concentrations. Serum was collected from 18 nonpregnant, control women, from 58 normal pregnant women during the first (n = 13), second (n = 15), and third (n = 30) trimesters, and from 25 preeclamptic patients at 27-39 weeks' gestation. All samples were assayed for sICAM-1 by a specific enzyme-linked immunoassay and for fibronectin by a nephelometric system. Serum sICAM-1 levels in preeclamptic patients were compared to those obtained from gestational-matched normal pregnant women. Levels of sICAM-1 were significantly elevated (P < 0.001) in each of the three trimesters of normal pregnancy (I trimester: 390.4 +/- 25.7 ng/ml; II trimester: 386.3 +/- 15.4 ng/ml; and III trimester: 367.3 +/- 15.8 ng/ml) when compared to those of healthy nonpregnant women (263.3 +/- 11.6 ng/ml). No significant difference in sICAM-1 concentrations was observed among the three trimesters. Preeclampsia was associated to a signifi...Continue Reading

References

Sep 16, 1992·Biochemical and Biophysical Research Communications·R PigottA J Gearing
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Citations

Jun 1, 2002·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Jacek R WilczyńskiJan Wilczyński
Jan 26, 2002·American Journal of Obstetrics and Gynecology·Hidefumi SasakiLan Bo Chen
Jan 13, 2018·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Nikolina DochevaOffer Erez
Oct 16, 2004·Journal of Korean Medical Science·Shin-Young KimEun Hee Cho
Aug 21, 2007·Obstetrical & Gynecological Survey·Henrik FalconerGabriel Fried
Apr 12, 2002·Endocrine Reviews·Fernando M ReisFelice Petraglia
May 29, 2004·Obstetrical & Gynecological Survey·Khalid FaragWilliam L Ledger

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