Soluble interleukin-2 receptor and soluble CD8 in liver cirrhosis and obstructive jaundice

Clinical and Experimental Immunology
F WagnerM Classen

Abstract

Activated lymphocytes secrete soluble interleukin-2 receptor (sIL-2R); CD8-positive lymphocytes secrete soluble CD8 (sCD8). Liver dysfunction in cirrhosis and obstructive jaundice is known to result in depressed cellular immunity. To evaluate whether this is due to real inactivation of the immune system, we measured sIL-2R and sCD8 in the serum of 46 patients with liver cirrhosis, 25 patients with obstructive jaundice, 32 patients with alcoholic liver disease without evidence of cirrhosis, 23 healthy persons and 43 patients with unrelated disease. sIL-2R in patients with cirrhosis (mean +/- s.e.m. 1499 +/- 140 U/ml) and obstructive jaundice (1517 +/- 204) was significantly increased compared with healthy subjects (363 +/- 29) and patients with unrelated diseases (685 +/- 92); sCD8 was significantly increased in patients with cirrhosis (737 +/- 63) but not in patients with obstructive jaundice (419 +/- 32) compared with healthy subjects (322 +/- 23) and patients with unrelated diseases (375 +/- 22). No difference was found between patients with cirrhosis due to alcohol abuse (n = 15) and chronic hepatitis B (n = 6). The Child-Pugh score had no significant influence on the sIL-2R or sCD8 value. In obstructive jaundice, sIL-2R cor...Continue Reading

References

Dec 1, 1979·American Journal of Surgery·J M HolmanF G Moody
Jan 1, 1977·Scandinavian Journal of Gastroenterology·G HusbyE Gjone
Oct 1, 1989·Digestive Diseases and Sciences·A AlbertiG Pizzolo
Nov 1, 1989·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·K YoshiokaM Inoue
Mar 1, 1989·Clinical Immunology and Immunopathology·M N ManoussakisH M Moutsopoulos
May 1, 1989·Clinical Immunology and Immunopathology·J A Teodorczyk-InjeyanW J Peters
May 1, 1987·Clinical Immunology and Immunopathology·R B ColvinA B Cosimi
May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M S LoughnanG J Nossal
Jun 1, 1988·Arthritis and Rheumatism·R E Wolf, W G Brelsford
Jul 1, 1988·The American Journal of the Medical Sciences·T D FeducciaJ B Grogan
Sep 1, 1988·The Journal of Surgical Research·D W VaneJ L Grosfeld
Aug 1, 1973·The British Journal of Surgery·R N PughR Williams
Mar 1, 1974·The American Journal of Digestive Diseases·M R BerenyiD Cruz
Nov 15, 1983·International Journal of Cancer. Journal International Du Cancer·T NakamuraM Tsuchiya
Jan 1, 1984·Computer Programs in Biomedicine·A K Thakur
Mar 1, 1984·The British Journal of Surgery·C P ArmstrongG C Davies
Sep 1, 1983·The British Journal of Surgery·S L BlameyD C Carter
Jan 1, 1981·American Journal of Surgery·H A PittT R Gadacz
Mar 1, 1982·The Journal of Surgical Research·J M Holman, L F Rikkers
Aug 1, 1980·Clinical Immunology and Immunopathology·M Pinto, A Kaplun

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