Soluble interleukin-2 receptor and soluble CD8 antigen in active rheumatoid arthritis

Clinical Immunology and Immunopathology
C C ZielinskiC Müller

Abstract

Concentrations of soluble interleukin-2 receptor (sIL-2R) and of soluble CD8 antigen (sCD8) in sera and in supernatants of phytohemagglutinin (PHA)-stimulated peripheral blood mononuclear cells (PBMC) derived from patients with active rheumatoid arthritis (RA) were studied. sIL-2R concentrations in sera derived from patients with RA (1484 +/- 382 U/ml) were significantly higher than in sera derived from healthy controls (380 +/- 110 U/ml; P less than 0.0005). In contrast, supernatants of PHA-stimulated PBMC derived from patients with RA contained similar amounts of sIL-2R (727 +/- 467 U/ml) as those derived from healthy control individuals (833 +/- 508 U/ml; P greater than 0.1). When investigated for the presence of sCD8 antigen, sera derived from patients with RA contained significantly lower amounts (30 +/- 28 U/ml) than sera derived from healthy controls (405 +/- 136 U/ml; P less than 0.0005). Similarly, PHA stimulation of PBMC derived from patients with RA resulted in a significantly lower production of sCD8 (35 +/- 46 U/ml) as compared to the one obtained by PHA stimulation of PBMC derived from healthy controls (177 +/- 59 U/ml; P less than 0.0005). This difference could not be explained by a lower proliferative response t...Continue Reading

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Citations

Feb 1, 1994·Journal of Hepatology·F PfeffelC Müller
Apr 15, 1999·Nature Medicine·A K SewellB K Jakobsen
Feb 1, 1994·Clinical and Experimental Immunology·E Di CesareD Cucinotta
Nov 1, 1991·Clinical and Experimental Immunology·M E NorthJ Farrant
Jun 1, 1993·Clinical and Experimental Immunology·N LahatG Merin

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