Soluble interleukin-2 receptor in children with reflux nephropathy

The Journal of Urology
R KondaS Orikasa

Abstract

Serum soluble interleukin-2 receptor level is a sensitive and quantitative marker of lymphocyte activation. We determined levels of serum soluble interleukin-2 receptor in children with reflux nephropathy to evaluate its clinical significance in the prediction for the progression of renal injuries. Serum soluble interleukin-2 receptor values were determined in 63 children with reflux nephropathy. The group consisted of 37 boys and 26 girls 10 to 18 years old. T cells (naive and memory), B cells and macrophages were evaluated immunohistochemically in the scarred kidneys of 4 other patients (3 boys and 1 girl 5 to 16 years old) who underwent nephrectomy due to severe reflux nephropathy with little function seen on (99m)technetium-dimercapto-succinic acid (DMSA) renal scan. Levels of serum soluble interleukin-2 receptor were measured by an enzyme-linked immunosorbent assay. We simultaneously determined serum levels of creatinine and beta2-microglobulin, and urinary levels of alpha1-microglobulin and microalbumin. Individual functions of the right and left kidneys were estimated by renal dimercaptosuccinic acid uptake. Levels of serum soluble interleukin-2 receptor in the patients who had low total uptake of DMSA (right uptake plus...Continue Reading

References

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Citations

Jun 8, 2000·Clinica Chimica Acta; International Journal of Clinical Chemistry·K EveraertJ Delanghe
Jan 10, 2001·Current Opinion in Urology·S Agarwal
Jul 10, 2020·Biomarkers in Medicine·Flávia C ValérioAna Cs E Silva

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