Soluble interleukin-2 receptor in stage I-III melanoma

Cytokine
Alessandro OttaianoGiuseppe Castello

Abstract

The aim of the present study was to assess the prognostic value of soluble interleukin-2 receptor (sIL-2R) serum levels in stage I-III melanoma patients. The levels of sIL-2R were determined using an enzyme immunometric test kit in 329 patients affected by malignant melanoma (MM) from 1995 to 2004. Correlations between sIL-2R values, baseline patients and tumour features were studied by contingency tables and the chi-square test. The Kaplan-Meier product limit method was applied to plot disease-free survival (DFS) curves. Univariate analysis was performed with the Log-rank test. Cox proportional-hazards regression was used to analyse the effect of several risk factors on DFS. In total, 2330 blood samples were collected during follow-up of 329 MM patients. Forty-five (13.7%) patients had Breslow tumour thickness<or=1.00, 83 (25.2%) patients>1.00 and <or=2.00 mm, 72 (21.9%) patients>2.00 and <or=4.00 mm, and 47 (14.3%) patients>4.00 mm. Ulceration was present in 64 cases (19.4%). Thirty-nine sentinel lymph nodes (SLNs) (11.8%) were infiltrated by MM. Soluble IL-2R values ranged from 130 to 1420 U/ml; median value was 500 U/ml. One hundred twenty-one (36.8%) patients presented with sIL-2R>600 U/ml at first measure (FM), 194 patien...Continue Reading

References

Sep 1, 1992·Annals of Oncology : Official Journal of the European Society for Medical Oncology·A GauseM Pfreundschuh
May 1, 1995·Cancer Immunology, Immunotherapy : CII·T PalomaresE Barberá-Guillem
Jan 1, 1995·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·B KleinT Klein
Oct 1, 1993·Melanoma Research·S CarrelD Rimoldi
Aug 19, 1993·International Journal of Cancer. Journal International Du Cancer·S PlaisanceC Jasmin
Jan 1, 1996·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·A García de GaldeanoM L Cañavate
Sep 1, 1997·Oncology·M D BoyanoJ L Díaz-Pérez
Apr 1, 1999·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·G BrunettiG Bernardo
May 3, 2001·Journal of the National Cancer Institute·A JemalM A Tucker
Aug 31, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M S VuoristoP Kellokumpu-Lehtinen
Apr 12, 2002·Current Pharmaceutical Design·F PerroneUNKNOWN Cancer of Liver Italian Program (CLIP) Investigators
May 15, 2002·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·A García de GaldeanoM L Cañavate
Oct 11, 2002·Annals of Surgical Oncology·Peter J Allen, Daniel G Coit
Apr 27, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John F ThompsonVernon K Sondak

❮ Previous
Next ❯

Citations

Jan 16, 2007·Archives of Dermatological Research·Jochen UtikalSelma Ugurel
Aug 5, 2014·BioMed Research International·Akinori MasudaTakao Kamai
Jan 23, 2010·Melanoma Research·Roger MouawadDavid Khayat
May 11, 2010·Journal of Cancer Research and Clinical Oncology·Maja A HofmannUwe Trefzer
Oct 2, 2007·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·E Bien, A Balcerska
Oct 18, 2008·Immunobiology·Julia DriesenJoachim L Schultze

❮ Previous
Next ❯

Related Concepts

Related Feeds

B-Cell Leukemia (Keystone)

B-cell leukemia includes various types of lymphoid leukemia that affect B cells. Here is the latest research on B-cell leukemia.