Soluble interleukin-2 receptor is a sensitive diagnostic test in adult HLH

Blood Advances
Anna HaydenLuke Y C Chen

Abstract

Serum soluble interleukin-2 receptor (sIL-2r) is an important disease marker in hemophagocytic lymphohistiocytosis (HLH), but there are no published data on its diagnostic value in adults. We conducted a single-center retrospective study of 78 consecutive adults who had sIL-2r measured for suspected HLH. Serum sIL-2r levels were measured by enzyme-linked immunosorbent assay (adult reference range, 241-846 U/mL). There were 38 patients with HLH and 40 with a non-HLH diagnosis (such as sepsis, liver disease, histiocyte disorders, autoimmune disease, leukemia, or lymphoma). The receiver operating characteristic curve demonstrated that sIL-2r is a good to excellent diagnostic test for adult HLH, with an area under the curve (AUC) of 0.90 (95% confidence interval, 0.83-0.97) compared with AUC 0.78 (95% confidence interval, 0.67-0.88) for ferritin. The optimal threshold for sIL-2r was 2515 U/mL (sensitivity, 100%; specificity, 72.5%). Although there was a large indeterminate range for sIL-2r, a level of 2400 U/mL or less was helpful for ruling out HLH (sensitivity, 100%), and more than 10 000 U/mL was helpful for ruling in HLH (specificity, 93%). Higher mean sIL-2r levels were seen in malignancy-associated HLH (20 241 U/mL) compared ...Continue Reading

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Citations

Sep 12, 2018·British Journal of Haematology·Luke Y C ChenAndre Mattman
Nov 28, 2018·American Journal of Hematology·Chelsea Kennedy-SnodgrassMarc Braunstein
Sep 1, 2019·Clinical Chemistry and Laboratory Medicine : CCLM·Shunzong YuanShiping Song
Dec 27, 2019·Critical Care Medicine·Gunnar LachmannClaudia Spies
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Mar 25, 2020·Critical Care Medicine·Gunnar LachmannClaudia Spies
Feb 23, 2020·Journal of Cancer Research and Clinical Oncology·Sebastian BirndtPaul La Rosée
Feb 29, 2020·Blood·Scott W Canna, Rebecca A Marsh
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Aug 10, 2019·Der Anaesthesist·Gunnar LachmannHolger Müller-Redetzky
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