Soluble interleukin 2 receptor (sIL-2R) levels in renal transplant recipients

Clinical Transplantation
Rajil MehtaDilip Kittur

Abstract

Allograft rejection is associated with T cell activation. T cell activation leads to secretion of soluble IL-2 receptor and elevated serum soluble IL-2 receptor (sIL-2R) levels. However, the clinical implication of individual elevated sIL-2 receptor levels is unclear. We followed levels of sIL-2R pre- and post-transplantation to determine if sIL-2R levels predict rejection episodes or degree of graft function. Serum samples of 12 patients who underwent living or cadaveric renal transplant were followed weekly with serial sIL-2R levels. These levels were followed until the serum creatinine reached a baseline. Of the 12 patients, three patients developed delayed graft function. The remaining nine patients were followed for a period of 3 months. Sera of these nine patients in the initial 3 months post-transplant were monitored for sIL-2R levels. For comparison, sIL-2R levels were also measured in 150 healthy volunteers and five dialysis patients. Recipients undergoing severe rejection episodes had higher overall serum levels of sIL-2R (1515 +/- 496 U/mL) as compared with recipients who had stable renal transplants and no episodes of rejection (698 +/- 333 U/mL) (P = 0.034). Comparison of sIL-2R ratios (post-transplant sIL-2R level...Continue Reading

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Citations

Mar 22, 2013·International Urology and Nephrology·Stela Zivčić-ĆosićZlatko Trobonjača
Aug 8, 2015·Clinical Biochemistry·Eberhard Wieland, Maria Shipkova
May 26, 2009·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·Dagistan Tolga AriozMehmet Yilmazer
Oct 18, 2008·Immunobiology·Julia DriesenJoachim L Schultze
Apr 12, 2012·Pediatric Transplantation·Vikas R Dharnidharka
Mar 4, 2006·Expert Review of Molecular Diagnostics·Qiuheng Zhang, Elaine F Reed
Oct 2, 2007·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·E Bien, A Balcerska
Mar 16, 2016·Therapeutic Drug Monitoring·Mercè BrunetMichael Oellerich
Jun 12, 2019·International Journal of Clinical Oncology·Chen XiaoHongZhang Boheng

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