PMID: 2104181Jan 1, 1990Paper

Soluble interleukin-2 receptors and autoantibodies in the serum of healthy elderly individuals

Autoimmunity
M N ManoussakisH M Moutsopoulos

Abstract

Recently, we reported an increased incidence of various autoantibodies in a healthy elderly population (Group A, 64 subjects). Presently we examined whether there is variability in the expression of the age-associated immunological aberrations between different geriatric populations by extending our observations in another healthy elderly population (Group B, 119 subjects). We also determined the serum levels of soluble IL-2 receptors (sIL-2R) attempting to define the activation status of the immune system during senescence. Compared to non-elderly controls, healthy elderly individuals exhibited a significantly higher incidence of autoantibodies as well as significantly higher levels of sIL-2R in serum (p less than 0.001), the latter possibly suggesting the occurrence of lymphocytic activation during the ageing process. The overall prevalence of autoantibodies was statistically associated with the presence of raised sIL-2R levels in serum (p less than 0.005). These aberrant immunological phenomena were more frequent among the elderly of group A, compared to group B (p less than 0.005). In contrast to the uniform expression of various autoantibodies previously observed in group A, the autoantibody profile of group B consisted ma...Continue Reading

References

Jul 1, 1979·Mechanisms of Ageing and Development·J P PandeyC B Loadholt
Mar 1, 1989·Clinical Immunology and Immunopathology·M N ManoussakisH M Moutsopoulos
Aug 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D K WagnerI T Magrath
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Citations

Aug 1, 1995·Aging : Clinical and Experimental Research·K Potocka-PlazakJ Kocemba
Feb 24, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·S S YehM W Schuster
Apr 1, 1993·European Journal of Clinical Investigation·G N DalekosH M Moutsopoulos
Mar 17, 2004·Arthritis and Rheumatism·Akihiro WatanabeYoshinao Muro
Jun 22, 2017·Mediators of Inflammation·Krishna D BharwaniFrank J P M Huygen
Nov 15, 1997·Journal of the American Geriatrics Society·A J RosenthalR A Adler
Mar 8, 2002·Clinical and Experimental Immunology·R NjeminiT Mets

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