PMID: 8603002Feb 1, 1996Paper

Soluble interleukin-6 receptor as a prognostic factor in multiple myeloma. Finnish Leukaemia Group

British Journal of Haematology
K PulkkiR Lahtinen

Abstract

Interleukin-6 (IL-6) is a major growth factor for the clonal malignant plasma cells in multiple myeloma (MM). The effect of IL-6 may be enhanced by soluble IL-6 receptor (sIL-6R). As there is a clinical need for improved stratification of MM patients at diagnosis, we have studied the role of sIL-6R as a prognostic marker in 207 newly diagnosed MM patients. Serum sIL-6R concentration was above the upper reference limit in 47% of the patients at diagnosis. The concentrations of sIL-6R and two other prognostic factors, IL-6 and beta-2 microglobulin (beta 2M), were all significantly higher in the patients who died within 3 years compared with those who survived. However, serum sIL-6R did not show linear correlation with IL-6 or beta 2M levels. In univariate logistic regression analysis sIL-6R was a significant predictor of 3-year mortality. Kaplan-Meier analysis showed that raised levels of sIL-6r were associated with shorter survival. When the patients were stratified into four groups according to their serum IL-6 and sIL-6R levels the patients with normal serum levels of both parameters had clear survival benefit. As beta 2M was the most powerful prognostic factor in the multivariate analysis, the patients were also stratified ac...Continue Reading

Citations

Jan 11, 2005·British Journal of Haematology·Niels Frost AndersenNiels Abildgaard
Jun 27, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Marcello MaggioLuigi Ferrucci
Jun 10, 2008·Current Opinion in Hematology·Zhi-Wei LiJames R Berenson
Feb 27, 1999·Leukemia & Lymphoma·C MathiotC Sautès
Jun 7, 2005·Expert Opinion on Therapeutic Targets·Klaus PodarKenneth C Anderson
Oct 16, 1999·British Journal of Haematology·I TuressonF Wislöff
Jul 24, 1998·Clinical Chemistry and Laboratory Medicine : CCLM·B Dugué, E Leppänen
Nov 11, 2014·The Journal of Clinical Investigation·Tobias DechowUlrich Keller
Jul 9, 2003·Immunological Reviews·Teru HideshimaKenneth C Anderson
Jan 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·S A JonesG M Fuller
Jan 14, 1999·British Journal of Haematology·P I Croucher, J F Apperley
Mar 6, 2003·Reviews in Clinical and Experimental Hematology·Jean-Luc Harousseau
Aug 1, 1997·Leukemia & Lymphoma·S R Smith, L Morgan
Oct 21, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Y Le MeurV Praloran
Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine·A YokoyamaK Hiwada
Apr 20, 2004·Blood·Teru HideshimaKenneth C Anderson
Jan 18, 2006·British Journal of Haematology·Hiroshi YasuiKenneth C Anderson
Jun 15, 2017·Molecular Cancer Therapeutics·Kristen B LongGregory L Beatty
Apr 1, 1997·The Journal of Surgical Research·A A HavertyD J Bouchier-Hayes
May 1, 2021·Blood Cancer Journal·Timothy M SchmidtSaad Z Usmani
Jul 3, 2021·Cells·Jessica Burroughs GarcìaNicola Giuliani
Jul 20, 2005·Best Practice & Research. Clinical Haematology·Teru HideshimaKenneth C Anderson

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