Soluble Klotho and Brain Atrophy in Alcoholism

Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism
Emilio González-ReimersFrancisco Santolaria-Fernández

Abstract

Fibroblast growth factor (FGF-23) and α-Klotho (Klotho) levels may be altered in inflammatory conditions, possibly as compensatory mechanisms. Klotho exerts a protective effect on neurodegeneration and improves learning and cognition. No data exist about the association of Klotho and FGF-23 levels with brain atrophy observed in alcoholics. The aim of this study is to explore these relationships. FGF-23 and Klotho levels are altered in inflammation, possibly as compensatory mechanisms. Klotho enhances learning, but its role in ethanol-mediated brain atrophy is unknown. We found higher FGF-23 and lower Klotho levels in 131 alcoholics compared with 41 controls. Among cirrhotics, Klotho was higher and inversely related to brain atrophy. The study was performed on 131 alcoholic patients (54 cirrhotics) and 41 age- and sex-matched controls, in whom a brain computed tomography (CT) was performed and several indices were calculated. Marked brain atrophy was observed among patients when compared with controls. Patients also showed higher FGF-23 and lower Klotho values. However, among cirrhotics, Klotho values were higher. Klotho was inversely related to brain atrophy (for instance, ventricular index (ρ = -0.23, P = 0.008)), especially i...Continue Reading

References

Sep 20, 2002·Nature·Geert J P L KopsBoudewijn M T Burgering
Aug 27, 2005·Science·Hiroshi KurosuMakoto Kuro-o
Sep 28, 2005·The Journal of Biological Chemistry·Masaya YamamotoMakoto Kuro-o
Dec 6, 2005·Biochemical and Biophysical Research Communications·Masashi IkushimaToshio Ogihara
Feb 3, 2012·Physiological Reviews·Aline MartinL Darryl Quarles
Mar 8, 2012·Advances in Experimental Medicine and Biology·Ming Chang HuOrson W Moe
Jun 20, 2012·Journal of Neuroinflammation·Liya Qin, Fulton T Crews
Mar 8, 2013·Seminars in Nephrology·Ming Chang HuOrson W Moe
Oct 5, 2013·The American Journal of Pathology·Haitao GuJens Werner
Oct 30, 2013·Hemodialysis International·David A DrewMark J Sarnak
Dec 29, 2013·Acta Neuropathologica·Suzanne M de la Monte, Jillian J Kril
Apr 3, 2014·Alcoholism, Clinical and Experimental Research·John C UmhauMarkus Heilig
Jul 20, 2014·The Journal of Biological Chemistry·Ella ZeldichCarmela R Abraham
Dec 3, 2014·Molecular and Cellular Endocrinology·Nobuaki ItoGerald J Atkins
Dec 31, 2014·World Journal of Gastroenterology : WJG·Elisabetta CeniAndrea Galli
Mar 6, 2015·Biological & Pharmaceutical Bulletin·Yuki MasudaMorichika Konishi
Aug 25, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Michelle ShardellLuigi Ferrucci
Jan 6, 2016·European Journal of Clinical Investigation·Evangelia DounousiCarmine Zoccali
Feb 13, 2016·American Journal of Physiology. Renal Physiology·Csaba P Kovesdy, L Darryl Quarles
Apr 2, 2016·Mediators of Inflammation·Weiwei XiaHongbing Chen
Oct 6, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Dieter Haffner, Maren Leifheit-Nestler
Nov 25, 2016·Experimental and Therapeutic Medicine·Andrzej PrystupaGrzegorz Dzida
Mar 23, 2017·Ageing Research Reviews·Marina Minto Cararo-LopesDaniel Charles Berwick
Jun 28, 2017·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Geraldine Quintero-PlattFrancisco Santolaria-Fernández
Nov 1, 2017·Scientific Reports·Stefanie KrickMatthias Salathe

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Citations

Mar 13, 2019·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·C Martín-GonzálezF Santolaria-Fernández
Apr 30, 2019·Frontiers in Psychiatry·Shui-Hua WangYu-Dong Zhang
Jun 23, 2020·Indian Journal of Critical Care Medicine : Peer-reviewed, Official Publication of Indian Society of Critical Care Medicine·Kapil Zirpe, Shrirang N Bamne

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