Abstract
The role of high-density lipoprotein (HDL) function and advanced glycation end products (AGEs) in HIV-related atherosclerotic cardiovascular disease (CVD) is unclear. Both glycation and oxidation (HDLox) are major modifications of HDL that can alter its composition and function. Therefore, we explored the longitudinal association of HDLox with progression of glycation, as evaluated by measurement of circulating forms of receptor for AGE that predict morbidity (soluble Receptors for Advanced Glycation Endproducts [sRAGE], endogenous secretory Receptors for Advanced Glycation Endproducts [esRAGE]), in people with HIV-1 (PWH; HIV-1) and uninfected (HIV-1) individuals.We retrospectively assessed if levels of plasma sRAGE and esRAGE and HDL function (reduced antioxidant function is associated with increased HDL lipid hydroperoxide content; HDLox) in a subset of participants (n = 80) from a prospective 3-year study (AIDS Clinical Trials Group A5078). Primary outcomes were baseline and yearly rates of change over 96 of 144 weeks (Δ) in HDLox in HIV-1 versus uninfected HIV-1 controls (noted as HIV-1).Higher baseline levels of sRAGE in PWH on effective anti-retroviral therapy and with low CVD risk, but not in HIV-1 persons, were indepen...Continue Reading
References
Mar 1, 1991·Diabetes·P B DuellE L Bierman
Nov 9, 1989·The New England Journal of Medicine·D J Gordon, B M Rifkind
Apr 18, 2000·Diabetologia·C C HedrickA L Peters
Feb 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Colomba FalconeDiego Geroldi
May 16, 2007·AIDS·Judith S CurrierHoward N Hodis
Dec 15, 2007·The Journal of Clinical Investigation·Evis HarjaAnn Marie Schmidt
Jun 9, 2009·Diabetes Care·Peter S KimColleen Hadigan
Jan 26, 2010·Biochemical Pharmacology·Shi Fang YanAnn Marie Schmidt
Apr 14, 2010·The Journal of Biological Chemistry·Giorgio CavigiolioMichael N Oda
Jul 1, 2010·Antiviral Therapy·Marshall J GlesbyKathryn Anastos
Jul 31, 2010·Aging Cell·Kellie McCormick HallamRavichandran Ramasamy
Feb 10, 2011·Nature Reviews. Cardiology·Mohamad NavabAlan M Fogelman
Jul 21, 2011·Diabetes·Helen M ColhounJohn H Fuller
Oct 1, 2011·Journal of Lipid Research·Theodoros KelesidisOtto O Yang
Jul 6, 2012·Acta Diabetologica·Francesco PiarulliAnnunziata Lapolla
Jan 1, 2013·Current Opinion in HIV and AIDS·Edwin LeeansyahJohan K Sandberg
Mar 21, 2013·Lipids in Health and Disease·Theodoros KelesidisJudith S Currier
Aug 30, 2014·Endocrinology and Metabolism Clinics of North America·Theodoros Kelesidis, Judith S Currier
Nov 5, 2014·PloS One·Theodoros KelesidisOtto O Yang
Aug 9, 2015·Diabetes·Gurdip DaffuAnn Marie Schmidt
May 25, 2016·Inflammation·Ann DanoffJudith A Aberg
Mar 28, 2017·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Theodoros KelesidisJudith S Currier
Sep 20, 2017·AIDS·Thomas A AngelovichTheodoros Kelesidis