Soluble ligands for the NKG2D receptor are released during endometriosis and correlate with disease severity

PloS One
Iñaki González-ForuriaCharles Chapron

Abstract

Endometriosis is a benign gynaecological disease. Abundant bulk of evidence suggests that patients with endometriosis have an immunity dysfunction that enables ectopic endometrial cells to implant and proliferate. Previous studies show that natural killer cells have a pivotal role in the immune control of endometriosis. This is a prospective laboratory study conducted in a tertiary-care university hospital between January 2011 and April 2013. We investigated non-pregnant, younger than 42-year-old patients (n= 202) during surgery for benign gynaecological conditions. After complete surgical exploration of the abdominopelvic cavity, 121 women with histologically proven endometriosis and 81 endometriosis-free controls women were enrolled. Patients with endometriosis were classified according to a surgical classification in three different types of endometriosis: superficial peritoneal endometriosis (SUP), ovarian endometrioma (OMA) and deep infiltrating endometriosis (DIE). Peritoneal fluid samples were obtained from all study participants during the surgery in order to detect soluble NKG2D ligands (MICA, MICB and ULBP-2). When samples with undetectable peritoneal fluid levels of MICA, MICB and ULBP-2 were excluded, MICA ratio lev...Continue Reading

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Citations

Nov 6, 2018·Molecular Human Reproduction·Katharina ProestlingLorenz Kuessel
Sep 22, 2019·Journal of Clinical Medicine·Aneta ŚcieżyńskaJacek Malejczyk
Jul 31, 2020·The Journal of International Medical Research·Jue HeGuohua Hu
May 10, 2017·Molecular Human Reproduction·Iñaki González-ForuriaFrédéric Batteux
Jul 15, 2020·Reproductive Sciences·Maria Lucia Carnevale MarinJorge Kalil

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

Statistical Package for the Social Sciences Software ( SPSS

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