PMID: 2118044Apr 1, 1990Paper

Soluble products of Staphylococcus aureus-stimulated blood mononuclear cells in enhancing polymorphonuclear leukocyte degradation of bone

Chinese Medical Journal
J H WangW J Gillespie

Abstract

Rapid, extensive loss of infected bone implies abnormal localized inflammatory cell activity. We have demonstrated, using a live bone Ca-45 release model, that polymorphonuclear leukocytes degrade bone in a dose dependent manner. Staphylococcus aureus-stimulated blood mononuclear leukocytes release soluble products in vitro that enhance that process. Despite the usually accepted roles of osteoclasts and their blood-borne monocytic precursors in normal bone remodelling, these results indicate that considerable early pathological infected bone loss may be attributable to inflammatory polymorphonuclear leukocytes.

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